The challenge for Bowles and defensive coordinator Kacy Rodgers will be drawing up a game plan to defend the playmaking Beckham, who has 72 catches for 1,005 yards and nine touchdowns this season.
Skrine, the Jets' primary nickel corner, has started 42 games during his five-year career and has 44 total tackles this season.
Walls has had limited action on defense this year while working mainly on special teams, but started 12 games last season for the Jets.
McDougle missed his rookie season last year with a knee injury, but has played in every game this season except the opener.
Milliner, the team's top pick in 2013, is still working his way back into the lineup after starting the season on short-term injured reserve because of a wrist injury.
Rueben Randle has 40 catches for 511 yards and four touchdowns, Dwayne Harris has 27 receptions for 332 yards and four TDs and running back Shane Vereen has 40 catches for 342 yards and three scores.
Pace was limited at practice and is questionable with a strained abdomen, while S Dion Bailey is doubtful with a sprained ankle.
Bowles on Giants DE Jason Pierre-Paul, who's looking for his first sack after missing the first eight games while recovering from a July 4 accident that seriously damaged his right hand: "Just looking at him on film, he's getting off the ball, like he always has," the Jets coach said.
