Others, like Two Egg, are dots on the map that get the occasional visitor curious about the name, but offer little besides a road sign — and even the sign often went missing until it was riveted in place.
Located about 70 miles northwest of Florida's capital, Tallahassee, Two Egg is a small farming community where people used to trade eggs for goods at the general store.
The store is no longer open, but people can still buy Two Egg cane syrup at a farm down the road.
Most visitors stop here on tour buses headed elsewhere, but some people make a special trip.
Melissa Brockman, executive director of the Spencer County Visitors Bureau, says Santa Claus was supposed to be named Santa Fe, but another Indiana town already had that name.
Stories vary about how this Louisiana border town got its name, says Randie Canup, owner of the Hoot 'n Holler guest cottage.
Shipping labels often peeled off in the humidity, and those boxes were marked "uncertain" and left at the final stop — which became known as Uncertain.
Cell phone coverage and Internet access are spotty but there's fishing, birding and scenery.
A radio station owner tired of people cracking jokes about the county suggested a name change at some point but local business owner Henry Kitchen started a "Save Our Butts" campaign with T-shirts and bumper stickers.
Shasta Brewing Company, plays it up — and got in trouble when the federal government objected to bottle caps that read A Friend in Weed is a Friend Indeed.