by Lorenzo Cianni, Carina Lemke, Erik Gilberg, Christian Feldmann, Fabiana Rosini, Fernanda dos Reis Rocho, Jean F. R. Ribeiro, Daiane Y. Tezuka, Carla D. Lopes, Sérgio de Albuquerque, Jürgen Bajorath, Stefan Laufer, Andrei Leitão, Michael Gütschow, Carlos A. Montanari
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by Kim Ozano, Laura Dean, Mami Yoshimura, Eleanor MacPherson, Natalia Linou, Mariam Otmani del Barrio, Christine M. Halleux, Olumide Ogundahunsi, Sally Theobald
by Hongwei Zhang, Jian Yang, Jiang Li, Jing Yang, Yunbao Yu, Guisheng Liu, Yongguo Zhang, Long Zhang, Wei Guo, Abuduwayiti, Hong Sun, Shuxia Guo, Xueling Chen, Xiangwei Wu, Shijie Zhang, Xinyu Peng
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by Carolina da S. G. Pedrosa, Leticia R. Q. Souza, Tiago A. Gomes, Caroline V. F. de Lima, Pitia F. Ledur, Karina Karmirian, Jimena Barbeito-Andres, Marcelo do N. Costa, Luiza M. Higa, Átila D. Rossi, Maria Bellio, Amilcar Tanuri, Arnaldo Prata-Barbosa, Fernanda Tovar-Moll, Patricia P. Garcez, Flavio A. Lara, Renato J. R. Molica, Stevens K. Rehen
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by Melissa Louise Sykes, David Hugh Hilko, Livia Isabella Kung, Sally-Ann Poulsen, Vicky Marie Avery
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by Francisco Goiana-da-Silva, Milton Severo, David Cruz e Silva, Maria João Gregório, Luke N. Allen, Magdalena Muc, Alexandre Morais Nunes, Duarte Torres, Marisa Miraldo, Hutan Ashrafian, Ana Rito, Kremlin Wickramasinghe, João Breda, Ara Darzi, Fernando Araújo, Carla Lopes
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by Hatem A. Wafa, Charles D. A. Wolfe, Ajay Bhalla, Yanzhong Wang
BackgroundThere have been reductions in stroke mortality over recent decades, but estimates by aetiological subtypes are limited. This study estimates time trends in mortality and functional dependence by ischaemic stroke (IS) aetiological subtype over a 16-year period.
Methods and findingsThe study population was 357,308 in 2011; 50.4% were males, 56% were white, and 25% were of black ethnic backgrounds. Population-based... Читать дальше...
With the postponement of Opening Day I figured the best thing for me to do is share more Dodger cards from Topps 2020 Opening Day Baseball card brand. This time, though I thought I would slow-play this by writing about one specific subset -- the "Walk this Way" set.
These cards appears to highlight walk-off hits, but unfortunately the cards do not specifically say this anywhere. I was hoping the reverse of the cards would have a description of the event being pictured, but all Topps does is use the back design from their flagship cards. Читать дальше...
by Alexandro Rodríguez-Rojas, Joshua Jay Kim, Paul Johnston, Olga Makarova, Murat Eravci, Christoph Weise, Regine Hengge, Jens Rolff
Читать дальше...Open-concept, luxury design covers 5,000 sq. ft. and is surrounded by a three-acre wooded lot
Meghan Markle’s farewell fashion was bright and cheery, seemingly matching her mood
by Michele Tizzoni, André Panisson, Daniela Paolotti, Ciro Cattuto
In recent years, many studies have drawn attention to the important role of collective awareness and human behaviour during epidemic outbreaks. A number of modelling efforts have investigated the interaction between the disease transmission dynamics and human behaviour change mediated by news coverage and by information spreading in the population. Yet, given the scarcity of data on public awareness during an epidemic, few studies have relied on empirical data. Читать дальше...
by Ryohei Shibue, Fumiyasu Komaki
Calcium imaging has been widely used for measuring spiking activities of neurons. When using calcium imaging, we need to extract summarized information from the raw movie beforehand. Recent studies have used matrix deconvolution for this preprocessing. However, such an approach can neither directly estimate the generative mechanism of spike trains nor use stimulus information that has a strong influence on neural activities. Here, we propose a new deconvolution... Читать дальше...
by Dmitrii S. Shcherbinin, Vlad A. Belousov, Mikhail Shugay
Antigen recognition by T-cells is guided by the T-cell receptor (TCR) heterodimer formed by α and β chains. A huge diversity of TCR sequences should be maintained by the immune system in order to be able to mount an effective response towards foreign pathogens, so, due to cooperative binding of α and β chains to the pathogen, any constraints on chain pairing can have a profound effect on immune repertoire structure, diversity and antigen specificity. Читать дальше...
by Benjamin Czaja, Mario Gutierrez, Gábor Závodszky, David de Kanter, Alfons Hoekstra, Omolola Eniola-Adefeso
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by Soyoung Park, Alice Jang, Sebastien G. Bouret
The steady increase in the prevalence of obesity and associated type II diabetes mellitus is a major health concern, particularly among children. Maternal obesity represents a risk factor that contributes to metabolic perturbations in the offspring. Endoplasmic reticulum (ER) stress has emerged as a critical mechanism involved in leptin resistance and type 2 diabetes in adult individuals. Here, we used a mouse model of maternal obesity to investigate... Читать дальше...
by Kotaro Tsuboyama, Tatsuya Osaki, Eriko Matsuura-Suzuki, Hiroko Kozuka-Hata, Yuki Okada, Masaaki Oyama, Yoshiho Ikeuchi, Shintaro Iwasaki, Yukihide Tomari
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by Delphine Gogendeau, Michel Lemullois, Pierrick Le Borgne, Manon Castelli, Anne Aubusson-Fleury, Olivier Arnaiz, Jean Cohen, Christine Vesque, Sylvie Schneider-Maunoury, Khaled Bouhouche, France Koll, Anne-Marie Tassin
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by Alexis T. Weiner, Dylan Y. Seebold, Pedro Torres-Gutierrez, Christin Folker, Rachel D. Swope, Gregory O. Kothe, Jessica G. Stoltz, Madeleine K. Zalenski, Christopher Kozlowski, Dylan J. Barbera, Mit A. Patel, Pankajam Thyagarajan, Matthew Shorey, Derek M. R. Nye, Matthew Keegan, Kana Behari, Song Song, Jeffrey D. Axelrod, Melissa M. Rolls
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by Derek M. R. Nye, Richard M. Albertson, Alexis T. Weiner, J. Ian Hertzler, Matthew Shorey, Deborah C. I. Goberdhan, Clive Wilson, Kevin A. Janes, Melissa M. Rolls
Читать дальше...There have been some media stories of late about the push by Martin Matthews against his forced resignation as Auditor-General due to the fraud committed by one of his direct reports when he was CE of the Ministry of Transport. I was unhappy at the time of the resignation that the Wevers report to the […]