by Zhijian Zhao, Wenqi Wu, Xiaolu Duan, Guohua Zeng, Yongda Liu
BackgroundThere has been significant uncertainty in the selection of candidates for cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (mRCC). This report investigates the influence of site-specific metastases (bone, brain, liver, and lung) on the survival benefit of CN.
MethodsWithin the Surveillance, Epidemiology and End Results database (2010–2014), 1113 mRCC patients treated with CN (n = 618) or no surgery (NS... Читать дальше...
by Jennifer Konczal, Justin Bower, Christopher H. Gray
Gene synthesis services have largely superseded traditional PCR methods for the generation of cDNAs destined for bacterial expression vectors. This, in turn, has increased the application of codon-optimized cDNAs where codons rarely used by Escherchia coli are replaced with common synonymous codons to accelerate translation of the target. A markedly accelerated rate of expression often results in a significant uplift in the levels of... Читать дальше...
by Melanie M. Domenech Rodríguez, Paula B. Phelps, H. Cathleen Tarp
PurposeCultural competence is a critical component in health care services. The relationship between health disparities and prejudice and discrimination is well documented. Prejudicial attitudes and discriminatory behavior are modifiable through training yet few programs have evidence-based training. No published data has reported on baseline levels of cultural competencies in medical trainees which is necessary for tailoring programs appropriate to the audience. Читать дальше...
by Michelle C. Coleman, Canaan M. Whitfield-Cargile, Rodolfo G. Madrigal, Noah D. Cohen
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by Masahiko Ayaki, Naoko Tachi, Yoshihiro Hashimoto, Motoko Kawashima, Kazuo Tsubota, Kazuno Negishi
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by Deus Thindwa, Megan Landes, Monique van Lettow, Annie Kanyemba, Ernest Nkhoma, Happy Phiri, Thokozani Kalua, Joep J. van Oosterhout, Evelyn J. Kim, Beth A. Tippett Barr, on behalf of the NEMAPP Consortium
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by Santosh K. Srivastava, Kelcey S. King, Nader F. AbuSara, Chelsea J. Malayny, Brandon M. Piercey, Jaime A. Wilson, Kapil Tahlan
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by Kana Miyamoto, Wataru Aoki, Yuta Ohtani, Natsuko Miura, Shunsuke Aburaya, Yusei Matsuzaki, Kaho Kajiwara, Yoshinori Kitagawa, Mitsuyoshi Ueda
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by Kristian Brat, Nela Stastna, Zdenek Merta, Lyle J. Olson, Bruce D. Johnson, Ivan Cundrle Jr.
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by Keir M. Balla, Vladimir Lažetić, Emily R. Troemel
Natural genetic variation can determine the outcome of an infection, and often reflects the co-evolutionary battle between hosts and pathogens. We previously found that a natural variant of the nematode Caenorhabditis elegans from Hawaii (HW) has increased resistance against natural microsporidian pathogens in the Nematocida genus, when compared to the standard laboratory strain of N2. In particular, HW animals can clear infection, while N2 animals cannot. Читать дальше...
by Suzanna M. Evans, Kingsley J. Griffin, Ray A. J. Blick, Alistair G. B. Poore, Adriana Vergés
by Yosuke Takeoka, Keitaro Matsumoto, Daisuke Taniguchi, Tomoshi Tsuchiya, Ryusuke Machino, Masaaki Moriyama, Shosaburo Oyama, Tomoyuki Tetsuo, Yasuaki Taura, Katsunori Takagi, Takuya Yoshida, Abdelmotagaly Elgalad, Naoto Matsuo, Masaki Kunizaki, Shuichi Tobinaga, Takashi Nonaka, Shigekazu Hidaka, Naoya Yamasaki, Koichi Nakayama, Takeshi Nagayasu
by Sherene Loi, Stefan Michiels, Jose Baselga, John M. S. Bartlett, Sandeep K. Singhal, Vicky S. Sabine, Andrew H. Sims, Tarek Sahmoud, J. Michael Dixon, Martine J. Piccart, Christos Sotiriou
by Joanna M. Davies, Katherine E. Sleeman, Javiera Leniz, Rebecca Wilson, Irene J. Higginson, Julia Verne, Matthew Maddocks, Fliss E. M. Murtagh
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by Dong (Roman) Xu, Shuiyuan Xiao, Hua He, Eric D. Caine, Stephen Gloyd, Jane Simoni, James P. Hughes, Juan Nie, Meijuan Lin, Wenjun He, Yeqing Yuan, Wenjie Gong
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by Hayley Warsinske, Rohit Vashisht, Purvesh Khatri
BackgroundThe World Health Organization (WHO) and Foundation for Innovative New Diagnostics (FIND) have published target product profiles (TPPs) calling for non-sputum-based diagnostic tests for the diagnosis of active tuberculosis (ATB) disease and for predicting the progression from latent tuberculosis infection (LTBI) to ATB. A large number of host-derived blood-based gene-expression biomarkers for diagnosis of patients with ATB have been proposed to date... Читать дальше...
by Gavin J. Churchyard, Sue Swindells
In a Perspective, Gavin Churchyard and Sue Swindells discuss the importance of strategies to target latent tuberculosis infection in high risk populations and thus disrupt a reservoir for new infections in high burden countries.
by Johan Vekemans, Katherine L. O’Brien, Jeremy Farrar
Johan Vekemans, Katherine O'Brien, and Jeremy Farrar discuss recent breakthroughs in the search for a highly effective tuberculosis vaccine.
by Santiago A. Cadena, George H. Denfield, Edgar Y. Walker, Leon A. Gatys, Andreas S. Tolias, Matthias Bethge, Alexander S. Ecker
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by Hannah Choi, Stefan Mihalas
Complex structural connectivity of the mammalian brain is believed to underlie the versatility of neural computations. Many previous studies have investigated properties of small subsystems or coarse connectivity among large brain regions that are often binarized and lack spatial information. Yet little is known about spatial embedding of the detailed whole-brain connectivity and its functional implications. We focus on closing this gap by analyzing how spatially-constrained... Читать дальше...
by Elizabeth A. McCullagh, Katarzyna Nowak, Anne Pogoriler, Jessica L. Metcalf, Maryam Zaringhalam, T. Jane Zelikova
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Shop more consciously and read on to discover some of the sustainable denim brands you must know about this Earth Day
Concept cars are big hits at auto shows, but the most daring designs rarely make it to production. They come in many shapes and sizes, are made for a variety of reasons, and can cost automakers millions to make. More »
Jon Fitch promises to teach Rory MacDonald and the other young whipper-snappers in the Bellator Welterweight Grand Prix a lesson.
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