Serie A official Week 25 line-ups: Inter vs. Juventus
Inter bring Nicolò Barella back with Lautaro Martinez and Marcus Thuram, but Juventus are forced to change with Kenan Yildiz, Francisco Conceicao and Jonathan David.
It kicks off at San Siro at 19.45 GMT (20.45 CET).
This is the Derby d’Italia, a notorious grudge match, not to mention a battle between two of the top five.
The last few editions have been thrilling, including a 4-4 draw at San Siro last season, and a 4-3 Juventus victory in Turin back in September.
Both Thuram brothers were on target that day, but this time around Khephren is out with a bruised leg and not even on the bench.
He joins Dusan Vlahovic and Arkadiusz Milik on the treatment table, so Fabio Miretti and Weston McKennie into a deeper midfield role than usual.
Conceicao shrugs off a knee issue to start with Yildiz and David upfront in what appears to be a 4-3-3 formation.
Inter have big news, as Barella and Hakan Calhanoglu returned to training on Tuesday after several weeks out, leaving just Denzel Dumfries on the absentee list.
Only the Italian is thrown straight into the starting XI with Piotr Zielinski and Petar Sucic, while Marcus Thuram partners Capocannoniere Lautaro Martinez.
They are running away at the top of the Serie A table, winning 11 of the last 12 games.
Inter vs. Juventus line-ups
Inter: Sommer; Bisseck, Akanji, Bastoni; Luis Henrique, Barella, Zielinski, Sucic, Dimarco; Lautaro Martinez, M Thuram
Juventus: Di Gregorio; Kalulu, Bremer, Kelly, Cambiaso; McKennie, Locatelli, Miretti; Conceicao, David, Yildiz