Serie A official line-ups: Napoli vs. Fiorentina
Napoli try to put Champions League disappointment behind them and focus on Serie A with Rasmus Hojlund, Scott McTominay and Antonio Vergara, while Fiorentina look to Albert Gudmundsson.
It kicks off at the Stadio Diego Armando Maradona at 17.00 GMT (18.00 CET).
The Partenopei crashed out of Europe on Wednesday with their 3-2 home defeat to Chelsea, as the epic injury crisis continues to take its toll.
There is no room for squad rotation, as Vanja Milinkovic-Savic is still not fully fit, with David Neres, Matteo Politano, Amir Rrahmani, Andre Frank Zambo Anguissa, Kevin De Bruyne and Billy Gilmour out.
Luca Marianucci was loaned to Torino today, with new signing Giovane on the bench after his debut as a substitute in the 3-0 defeat to Juventus.
The only changes from the side that lost to Chelsea are in position, with Miguel Gutierrez and Leonardo Spinazzola expected to swap flanks in a 3-4-2-1 formation.
Antonio Vergara continues to impress after his wonder goal against Chelsea, supporting Hojlund with Eljif Elmas.
Fiorentina remain in the relegation zone, but had certainly improved in 2026 with two wins and two draws before their 2-1 home loss to Cagliari.
They were knocked out of the Coppa Italia on Tuesday in a 3-1 defeat to Como as well.
Tariq Lamptey is the only remaining absentee, as Moise Kean is fit enough for a spot on the bench after a recurring ankle issue.
Roberto Piccoli, Dodo and Rolando Mandragora also shook off knocks, as the centre-forward had limped off during that Coppa Italia tie.
January buys Manor Solomon, Giovanni Fabbian, Marco Brescianini and Jack Harrison bolster the squad options.
Napoli vs. Fiorentina line-ups
Napoli: Meret; Di Lorenzo, Juan Jesus, Buongiorno; Gutierrez, Lobotka, McTominay, Spinazzola; Vergara, Elmas; Hojlund
Fiorentina: De Gea; Dodo, Pongracic, Comuzzo, Gosens; Fagioli; Solomon, Fabbian, Brescianini; Gudmundsson; Piccoli