Marco Verratti was replaced just before the break in Marseille-PSG with a suspected hip injury.
The former Pescara man started the game in the middle of the park at the Stade Velodrome but was forced off the pitch during the stoppages in the first half.
The Italy international picked up a knock to his hip in a challenge with Arsenal loanee Mattéo Guendouzi and received treatment by the PSG medical staff.
However, even after that, he could not continue the game so Idrissa Gueye was introduced.
Verratti, 28, has played six games across all competitions with the Ligue 1 giants so far this season.
It remains to be seen how long he will remain out of action with Italy that play their next games in November.
The Azzurri host Switzerland on November 12 and visit Northern Ireland three days later in their last two World Cup qualifying matches.
Verratti made his senior Azzurri debut in 2012 and has 48 caps and three goals to his name.
Choque, hielo… y cambio antes del final del PT: afuera Verratti del #Classique ante Marsella. pic.twitter.com/jl1ZAAbmzK
— SportsCenter (@SC_ESPN) October 24, 2021
