On October 8th, KAIST announced that the research team had successfully converted oxygen atoms in furan compounds into nitrogen atoms, transforming them into pyrrole structures commonly used in pharmaceuticals. This achievement, a world first, was published in 'Science' on October 3rd under the title "Photocatalytic Furan-to-Pyrrole Conversion."
Professor Park's team introduced a novel photocatalyst powered by light energy, which functions as a "molecular scissor" to selectively edit five-membered ring structures. This method allows for single-atom editing at room temperature and atmospheric pressure, a previously unattainable feat. The team's approach leverages light energy to replace traditional, harsh chemical conditions, offering high versatility for applications in natural products and complex pharmaceuticals.
"This foundational technology will transform how we build drug candidate libraries, a major challenge in the pharmaceutical industry," said Professor Park. The breakthrough has also been highlighted in the 'Perspective' section of 'Science', underscoring its significance to the scientific community.
Research Report:Photocatalytic furan-to-pyrrole conversion
