Real Betis currently resides in the upper half of the league at ninth, while its opponent Rayo Vallecano is in the bottom half at 12th.
Real Betis won its most recent match by a score of 2-1 over Villarreal CF away from home on December 15. Villarreal lost despite outshooting Real Betis 14 to 11.
In its most recent outing on December 18, Rayo Vallecano drew with Villarreal CF 1-1 on the road. Villarreal CF outshot Rayo Vallecano 12 to 11.
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Soccer odds courtesy of BetMGM Sportsbook. Odds updated Wednesday at 11:30 PM ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.