The Greek star made the French Open decider in 2021 and was a losing finalist to Novak Djokovic at the Australian Open in 2023 but is yet to take the final step.
He is coming off a mediocre 2024 season in which his ranking dropped to its current 11 from a career-high three, managing only one title, a repeat victory at Monte Carlo.
But the 26-year-old, who will lead his nation in Perth with a Sunday round-robin tie against Spain, is keen to bury the past and renew the charge to his longtime tennis goal.
"I was stuck in a rut last season and I needed to reflect," he said.
"You need to see what things are not serving you anymore and remove them -- get them out of your life.
"You need to refresh, restart, regroup, using those things that benefit what you are doing."
Tsitsipas said his defeat against 10-time Australian Open champion Djokovic nearly two years ago was a major learning experience.
"That (final) was my best memory on court ever, even if I lost. I was faced with a potential Grand Slam title, an important moment in my career," he said.
"And it was a childhood dream to finish (as) number one -- both of my goals were in front of me.
"This was the only time of life that felt like all was in my control. Unfortunately (victory) didn't happen but I was focused 100 percent. I get emotional thinking of how close I got to what I've dreamed of."
After his 2024 struggles, the Greek is keen to kick-start his comeback in Perth before another tilt at the Australian Open in January.
"It's a story of constant improvement," he said. "Last year I struggled, I'm not looking (necessarily) for happiness, just good memories. I want to start fresh and new in 2025."
