Enugu, back in the elite African club competition for the first time since 2017, should be too strong for Zilimadjou from the Comoros in the first round during August.
Assuming they clear that obstacle, Rangers would meet Saint Louis of the Seychelles or Esperanca Sagrada of Angola in September, and be favoured to succeed again and secure a group-stage place.
Every contender aspires to qualify for the 16-club mini-league phase as that is where prize money kicks in with minimum prize money of $700,000 (645,000 euros).
Remo, whose first Champions League appearance ended in the first round last season, must have hoped for an easier start than former title-holders FAR Rabat of Morocco.
Despite losing Tunisian coach Noureddine Nabi to South African outfit Kaizer Chiefs, FAR look capable of going far in a competition they won 39 years ago.
Remo or FAR will face a Libyan club yet to be named or vastly experienced African campaigners Al Merrikh of Sudan in the second round.
The last Nigerian winners of the Champions League were Enyimba in 2005.
Orlando Pirates, the first South African club to be crowned African champions, were drawn against debutants Disciples of Madagascar.
That seems a winnable tie for the Soweto outfit, who would then tackle African Stars of Namibia or Jwaneng Galaxy of Botswana.
Galaxy stunned Pirates in the second round last season, winning on penalties in South Africa after both achieved 1-0 victories at home.
The Botswana team then caused an even bigger shock by defeating three-time CAF champions Wydad Casablanca in Morocco before fading and finishing bottom of a group.
Kenyan club Gor Mahia, who won the now defunct African Cup Winners Cup in 1987, will be expected to get past Merreikh Bentiu from South Sudan.
But success in the second round is unlikely as Gor would face record 12-time champions and title-holders Al Ahly of Egypt.
After back-to-back final victories over Wydad Casablanca and Esperance of Tunisia, Ahly are hoping to become the first club to win the Champions League three times in a row.
The other Egyptian entrants, expensively-assembled Pyramids, could face AZAM of Tanzania in a last-32 tie.
Pyramids must first get past JKU of Zanzibar while AZAM were paired in the opening round with perennial underachievers APR of Rwanda, who have been busy bolstering their squad.
