In a career spanning over 20 years, Ramos carved himself a place in football history, winning the 2010 World Cup and two European championships with Spain as well as four Champions League titles with Real Madrid before going back to help struggling Sevilla survive a tricky season.
The 38-year-old Ramos racked up 37 appearances for Sevilla as they struggled to 14th in La Liga, getting through three coaches on the way.
Ramos left Sevilla at 19 for a 15-year spell at Real Madrid in 2005. He then spent two seasons at Paris Saint-Germain.
The inspirational defender has yet to reveal his destination for next season
The record seven-time Europa League winners said Ramos would bid farewell to fans on Tuesday after informing them on Monday his dream return to the club who brought him on from youth level was over.
"Sergio Ramos has informed Sevilla FC that he will not stay next season," the club said in a statement.
"The club wishes to thank Sergio for the commitment, leadership and dedication that he has demonstrated this season, and wishes him the best for future."
Sevilla captain and record appearance-maker Jesus Navas, also 38, left the club two weeks ago after 17 seasons.
