Repurposing mebendazole to reprogram oncogenic and tumor-suppressor networks: Multi-cancer insights from ENOX2, MMP2, RASSF1A, WFDC10A and METTL7A
by Rasha Shaker Aqel, Areej Sami Ismail, Mohamed El-Tanani, Shakta Mani Satyam
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by Rasha Shaker Aqel, Areej Sami Ismail, Mohamed El-Tanani, Shakta Mani Satyam
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by Kazi Md Azman Hossain, Suraiya Yesmin Sharna, Farzana Sharmin, Tofajjal Hossain, Jahid Hasan Naim, Al Amin, Touhidul Islam Badhon
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by Xiancheng Xiong, Chen Zhong
Tourism development is increasingly linked to both regional economic activity and environmental outcomes. However, empirical evidence remains limited on whether and through which channels proximity to major tourist attractions is associated with the environmental governance of industrial enterprises. Using enterprise-level data and geocoded locations of China’s national 5A tourist attractions in 2014, we examine the relationship between firms’ spatial proximity... Читать дальше...
by Karin Törnbom, Gunnel E. Carlsson, Katharina S. Sunnerhagen
BackgroundEarly supported discharge (ESD) facilitates the transition from specialized stroke units to home-based rehabilitation in familiar environments. While ESD has shown positive outcomes for people with stroke, little is known about how their family caregivers experience this transition and the support available once ESD ends. This qualitative study explores the needs, challenges, and expectations of family caregivers... Читать дальше...
by Martine Asobasi, Saidi Appeli, Peter Omara, Solomon Olum
BackgroundHunger and malnutrition are major global issues particularly in conflict and disaster-affected areas. Own food production has been considered as effective strategy to improve nutrition outcomes. However, evidence on its contribution to dietary diversity and nutrient intake adequacy, especially in refugee settings with limited access to land remains limited. This study assessed the contribution of own food production... Читать дальше...
by Jannatunnesa Jannatunnesa, Nurul Shahnaz Mahdzan, Abu Hanifa Md Noman
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by Elias Edward Tannous, Shlomo Vinker, David Stepensky, Eyal Schwarzberg
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by Jun Kawabata, Kenichi Goto, Megumi Maeda, Haruhisa Fukuda
Outcomes related to health status and economic burden among patients who experienced critical COVID-19 remain insufficiently studied. We examined 180-day post-discharge mortality and total medical expenditures in COVID-19 patients according to their use of mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO) during hospitalization. Using medical claims data from a Japanese municipality, this retrospective cohort... Читать дальше...
by Noriyuki Misaki, Kayoko Sato, Kaede Yamada, Naoya Yokota, Natsumi Matsuura, Toshiki Yajima
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by Nidhi Gupta, Sruthi Sunil, Kamran Ali, Trine Fink, Xiangyun Du
Learner agency (LA), a student’s ability to take ownership of their learning and make purposeful decisions, is increasingly recognized as a critical competency in preparing adaptable healthcare professionals. While LA has been explored in general education, its development within dental education, particularly in the context of problem-based learning (PBL), remains underexplored. This qualitative study investigated undergraduate... Читать дальше...
by Josephine Vanessa Nakalema, Marvin Musinguzi, Deo Benyumiza, Eustes Kigongo, Edward Kumakech, Rashida Namuwaya, Joshua Oryem Opido, Nicholas Damulira, Raymond Tumwesigye, Amir Kabunga, Marc Sam Opollo
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by Emily Robb, Sarah Muise, Lana Watt, Rebecca Armstrong, Duncan Wells, Paul McCusker, John Harrington, Andreas Krasky, Paul M. Selzer, Nikki J. Marks, Aaron G. Maule
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by Andie I. Lun, Barbara de Barros, Stephen L. Walker
BackgroundLeprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae) and Mycobacterium lepromatosis (M. lepromatosis), primarily affecting the skin and peripheral nervous system. Leprosy is complicated by immune-mediated reactions which are risk factors for nerve damage and disability. Systemic corticosteroids are the mainstay of therapy; however, prolonged use in chronic or recurrent reactions carries significant... Читать дальше...
by Hong Xiao, Guanin Bai, Fang Liu, Yuechong Cui, Joseph M. Unger
BackgroundThe COVID-19 pandemic has profoundly impacted healthcare systems worldwide, with China presenting a unique case. As the first country to report COVID-19 cases and the last to lift its stringent Zero-COVID policy, China presents a distinctive context for understanding the long-term effects of the pandemic on healthcare utilization. This study provides a comprehensive analysis of healthcare utilization trends in China over more than four years of the pandemic... Читать дальше...
by Yu-Jung Jenny Wei, Almut G. Winterstein, Roger B. Fillingim, Stephan Schmidt, Siegfried Schmidt
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by Binh Nguyen, Katherine B. Owen, Mengyun Luo, Wendy Brown, Gregore I. Mielke, Philip J. Clare, Ding Ding
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by Eliano P. Navarese, Paul Gurbel, Udaya Tantry, Giuseppe Talanas, Klaudyna Grzelakowska, Julia Umińska, Young-Hoon Jeong, Kevin Bliden, Safi U. Khan, Jacek Kubica, Timothy D. Henry, Michael E. Farkouh, Dean J. Kereiakes
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by Sichen Zhu, Zhengqi Wang, Kevin Bunting, Peng Qiu
Bulk RNA sequencing (bulk RNA-seq) and single-cell RNA sequencing (scRNA-seq) are two important high-throughput sequencing platforms that have wide applications in biomedical research. Bulk RNA-seq reflects the average gene expression of all cells in the sample at a low experimental cost, whereas scRNA-seq enables transcriptomics profiling at a single-cell level, although with higher experimental costs. To integrate the strengths of both... Читать дальше...
by Martin Bagic, Arian Šajina, William John Bradshaw, Dario Riccardo Valenzano
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by Zachary G. L. Scurlock, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray, Anton J. Enright
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by Ruwini Rupasinghe, Brittany L. Morgan Bustamante, Rebecca C. Robbins, Maria J. Clavijo, Beatriz Martínez-López
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by Liyne Nogay, Ananthakrishnan Vijayakumar Maya, Lara Heckmann, Francesco Cardamone, Isabelle Grass, Aakriti Singh, Anna Frey, Laurin Ernst, Nicola Iovino, Anne-Kathrin Classen
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