The US military has suffered losses in its fight with Iran. 3 American service members have been killed.

• Three American service members have been killed as part of combat operations against Iran.
• Five more were seriously wounded, the military said on Sunday.
• It marks the first confirmed US losses since strikes began alongside Israel on Saturday.

Three American service members have been killed and five seriously wounded as part of combat operations against Iran, the US military said on Sunday.

It is the military's first acknowledgement of any US losses since American forces began striking Iran alongside Israel on Saturday.

"Several others sustained minor shrapnel injuries and concussions — and are in the process of being returned to duty," said US Central Command, which oversees Middle East operations. It did not specify how or where the service members were killed and wounded.

"The situation is fluid, so out of respect for the families, we will withhold additional information, including the identities of our fallen warriors, until 24 hours after next of kin have been notified," CENTCOM said in a statement, adding that combat operations will continue.

President Donald Trump said on Saturday that the US could suffer losses as a result of the conflict with Iran.

"The lives of courageous American heroes may be lost, and we may have casualties. That often happens in war," Trump said in a video address to the nation. "But we're doing this — not for now — we're doing this for the future, and it is a noble mission."

Dozens of people have been killed and wounded by Iranian strikes in Israel and the United Arab Emirates, and hundreds of people in Iran have been killed and wounded by US and Israeli strikes, according to local authorities.

The Israeli military said on Sunday that it has killed 40 senior Iranian commanders, as well as the country's Supreme Leader Ayatollah Ali Khamenei.