The 27-year-old returns to the ring in Riyadh after making a spectacular first defence of his IBF belt against Anthony Joshua.
Dubois knocked out his British rival inside five rounds at Wembley Stadium in September.
Parker held the WBO title between 2016 and 2018 before losing a unanimous points decision to Joshua.
The 32-year-old New Zealander upset former WBC champion Deontay Wilder last year before beating Zhilei Zhang to win the WBO interim title in March.
