I greatly enjoyed tooting with my mouse in Trombone Champ on a flat monitor, but in retrospect it's the perfect candidate for conversion to virtual reality. It's small in scope, for one, but also VR would let you see through the eyes of the tooter and slide your trombone note up and down by holding the motion controllers up to your face.
So it is in Trombone Champ: Unflattened, a VR spin-off that's out now.