Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets

Journal List Cancers (Basel) PMC8833388 As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Cancers (Basel). 2022 Feb; 14(3): 664. Published online 2022 Jan 28. doi:10.3390/cancers14030664PMCID: PMC8833388PMID: 35158934Alexandros Karagiannakos,1 Maria Adamaki,1 Antonis Tsintarakis,1 Borek Vojtesek,2 Robin Fåhraeus,2,3,4,5 Vassilis Zoumpourlis,1,*† and Konstantinos Karakostis1,3,6,*†Constantin N. Baxevanis, Academic EditorAuthor information Article notes Copyright and License information PMC DisclaimerAssociated DataSupplementary MaterialsAbstractSimple SummaryCurrently, genomic databases offer a vast amount of information on mutational profiles and records of statistically significant genetic associations with diseases. However, the functional interpretation of frequently mutated genes implicat...