The introduction of electronic cigarettes (e-cigarettes) in recent years has created new dilemmas for clinical and research communities. E-cigarettes are battery-powered devices that heat liquids containing nicotine, flavoring, and other substances to create aerosols. Their use is often called “vaping.” E-cigarettes have been marketed as safer alternatives to cigarettes because they do not contain the carcinogens found in combustible tobacco products. More than 4.5% of US adults, 10% of high school students, and 4.6% of middle school students report currently using e-cigarettes.