Recent research at the Institute of Molecular Biology and Biotechnology (IMBB) of the Foundation for Research and Technology-Hellas (FORTH), at the Paris Cité University, and at the University of Graz, published today in Nature Cell Biology, sheds light on the mechanism through which spermidine regulates autophagy, a process that ensures the recycling of components within the cell, to promote the anti-aging effects of intermittent fasting.