US stocks gave up previous day gains to end lower on Wednesday as concerns about the outlook for the U.S. economy continued to hang over the markets. The major averages on the Wall Street ended the day just off their lows of the session. The Nasdaq slumped 171.05 points or 1.1 percent to 16,195.81, the S&P 500 slid 40.53 points or 0.8 percent to 5,199.50 and the Dow fell 234.21 points or 0.6 percent to 38,763.45. Tuesdays gains came as Bank of Japan offered investors some confidence after Deputy Governor Shinichi Uchida said the central bank will refrain from hiking interest rates when the markets are unstable.