“This is one of the most perilous moments in the [Middle East] region in years,” says Ali Vaez, director of the International Crisis Group Iran Project, after Israel’s assassination of Hamas political chief Ismail Haniyeh on Wednesday in Tehran. Iranian retaliation against Israel appears imminent. “All bets are off,” warns Vaez, adding that Israel’s latest maneuver will put Americans “in harm’s way,” as Iran will no longer hold back fellow Axis of Resistance members, especially Islamic militias in Iraq and Syria, from launching attacks on U.S. military bases in the region. “It is disastrous for a superpower who cannot control, basically, a client state that is destabilizing the region,” Vaez explains. We also hear from Palestinian human rights attorney Diana Buttu, who responds to Israel’s announcement that its July strike on al-Mawasi, an alleged safe zone in Gaza, killed Hamas military chief Mohammed Deif along with nearly a hundred civilians. Buttu argues it is Israel’s international impunity over the course of its campaign against Palestine that has led to this dangerous moment of escalation. “This is a monster that’s been unleashed,” she says. “This is going to spread, and this is exactly what Netanyahu wants.”