A Listly List - The fourth largest city and one of the four major cities in the Isan region, Khon Kaen has a history dating back to the 18th century. It is also the quality of silk produced that brings fame to the nation. As an eager visitor to Khon Kaen, find some of the best things to do in this modern city. - Phra That Kham Kaen Chedi, Ton Taan Night Market, Khon Kaen, Phra Mahathat Kaen Nakhon, and Kaen Nakhon Lake