Transmembrane β-barrel pores (TMBs) are extensively used for single-molecule DNA and RNA sequencing. They enable the miniaturization of a wide array of sensing and sequencing applications into portable USB-size devices and point-of-care technologies. A team of Belgian and American researchers has now described a general approach to designing TMB pores from scratch with custom shapes and properties, opening up new opportunities for single-molecule analytics. Their results were published in Science.
