Journal List Springer Nature - PMC COVID-19 Collection PMC7122703 As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Biology of C Reactive Protein in Health and Disease. 2016 Mar 24 : 67–107. Published online 2016 Mar 24. doi:10.1007/978-81-322-2680-2_4PMCID: PMC7122703Waliza Ansar3 and Shyamasree Ghosh4Author information Copyright and License information PMC DisclaimerAbstractThe knowledge of inflammation records dates back in first century AD. Initially discovered with features of rubor, tumor, calor, and dolor, scientific investigations have revealed chemical components, cells, and pathways involved in the process of inflammation. The body’s initial defense in response to infection, trauma, or inflammation is through the acute-phase response (APR). APR is a multifaceted set of systemic reac...
