India is ahead of several countries in drafting a legal framework to support the implementation of the 'One Health' initiative, which integrates the health of people, animals, and the environment. The 'One Health' approach is crucial for addressing complex health challenges such as zoonotic diseases, antimicrobial resistance, food safety, and climate change. India is framing National Action Plan 2.0 to address antimicrobial resistance issues, conceptualizing the One Health Mission, and working on broader issues of climate change.