The United States chased down a target of 195 to beat fellow non-Test nation Canada in their first Group A encounter but were now up against a far superior bowling attack.
Nevertheless, the United States could be proud of their efforts in the field against Pakistan given they reduced the 2009 T20 World Cup winners to 26-3 after winning the toss.
Left-arm spinner Nosthush Kenjige, who opened the bowling, took 3-30 -- including two wickets in two balls -- from his maximum four overs and left-arm paceman Saurabh Netravalkar a miserly 2-18.
Pakistan were in dire straits at 26-3 inside five overs before a partnership of 72 between skipper Babar Azam (44) and Shadab Khan (40).
Shadab and Azam Khan fell in successive balls to Kenjige.
Pakistan, runners-up to England at the last T20 World Cup in Australia two years ago, were faltering again at 98-5 before tailender Shaheen Shah Afridi's unbeaten 23 boosted the total.
Earlier, Mohammad Rizwan was superbly caught one-handed at slip by Steven Taylor off Netravalkar before Usman Khan holed out off Kenjige to leave Pakistan 14-2.
