Two complementary research articles reveal that central and peripheral circadian clocks coordinate to regulate the daily activity of skin and muscles. The coordination between the two clocks (central and peripheral) guarantees 50% of the circadian functions of tissues, including vital processes such as the cell cycle, DNA repair, mitochondrial activity, and metabolism. Synchronization between the central brain clock and peripheral ones prevents premature muscle aging and improves muscle function, suggesting new strategies to tackle age-related decline through circadian rhythm modulation.
