Scientists provide new evidence to motivate rapid fossil fuel phaseout. The science team determined exposure to ambient air pollution and its health impacts using an updated atmospheric composition model, a newly developed relative risk model and recent satellite-based fine particle data. They estimated all-cause and disease-specific mortality and attributed them to emission categories. They show that phasing out fossil fuels is a remarkably effective health-improving and life-saving intervention. About 5 million excess deaths per year globally could potentially be avoided.