Biomanufacturing based in space can improve the sustainability of deep space exploration. Bioprocessing systems to advance biomanufacturing for space applications need to be developed. In a new report now published in npj Microgravity, Mathangi Soundararajan and a team of scientists in bioengineering and space biosciences at the NASA Ames Research Center, California, have developed commercial technologies to design space bioprocessing systems that supply a liquid amine carbon dioxide scrubber with recombinant active carbonic anhydrase. The design workflows encompassed a biomass of 1 L of Escherichia coli cultures using recombinant protein purification.