McIlroy, Hovland to play all five Ryder Cup sessions
Luke Donald's men lead 9.5-2.5 and even a halved session would give them the biggest two-day lead since continental Europe joined the event in 1979.
Hovland will face Sam Burns and Collin Morikawa with Swedish sensation Ludvig Aberg, bidding to replicate their stunning 9 and 7 victory over Scottie Scheffler and Brooks Koepka in Saturday morning's foursomes.
"I almost pinch myself at times but obviously super happy with it and looking forward to this afternoon," said Aberg.
McIlroy joins up with Matthew Fitzpatrick for a second straight afternoon, taking on Patrick Cantlay and Wyndham Clark in the bottom match.
All 12 of Europe's players will have featured at least twice before Sunday's singles, with Justin Rose and Robert MacIntyre resuming their partnership against Justin Thomas and Jordan Spieth.
Nicolai Hojgaard, who also sat out both foursomes sessions, joins forces with Tommy Fleetwood for a clash with Max Homa and Brian Harman.
Homa and Harman grabbed the USA's only full point of the event so far by beating Shane Lowry and Sepp Straka on Saturday morning.
There was no place for Scheffler, Koepka or Rickie Fowler, who has not played since Friday morning.
Pairings for the second fourballs session (tee-off times GMT):
1025: Viktor Hovland and Ludvig Aberg (EUR) v Sam Burns and Collin Morikawa (USA)
1040: Tommy Fleetwood and Nicolai Hojgaard (EUR) v Max Homa and Brian Harman (USA)
1055: Justin Rose and Robert MacIntyre (EUR) v Justin Thomas and Jordan Spieth (USA)
1110: Matthew Fitzpatrick and Rory McIlroy (EUR) v Patrick Cantlay and Wyndham Clark (USA)