Head coach Pellegrino Matarazzo made two changes to the starting XI that lost 3-1 to 1. FC Cologne. Ozan Kabak and Munas Dabbur replaced Kevin Vogt and Finn Ole Becker.
TSG went into the game in 14th position with 29 points on the board. Leipzig, meanwhile, were in fifth place with 51 points.
After suffering an ankle injury in the reverse fixture against Leipzig, Grischa Prömel had to wait 175 days to make his Bundesliga comeback. The midfielder returned to first-team action with TSG for the first time on Saturday, making a substitute appearance in the 61st minute.
The 38th minute: TSG Hoffenheim had little in the way of chances in the first half but Ihlas Bebou should have scored the equaliser shortly before the interval. Munas Dabbur failed to beat Janis Blaswich following a cross from Pavel Kadeřábek and the loose ball landed at the feet of Bebou, who fired over from seven metres out with the goal gaping.
The 1-0 loss at RB Leipzig was Dennis Geiger's 100th Bundesliga match. The midfielder has played all of those games in a TSG Hoffenheim shirt.
TSG Hoffenheim will host Eintracht Frankfurt next Saturday. Kick-off is at 15:30 CET.
Line-ups
RB Leipzig: Blaswich – Klostermann, Orban, Gvardiol (Diallo, 60) – Simakan (Henrichs, 81), Laimer, Kampl, Raum (Halstenberg, 60) – Forsberg (Dani Olmo, 60), Nkunku (André Silva, 60) – Werner
TSG Hoffenheim: Baumann – Ozan Kabak, Brooks, Akpgouma – Kadeřábek (Skov, 69), Geiger (Rudy, 61), Angeliño (Nsoki, 46) – Kramarić, Baumgartner (Prömel, 61) – Bebou (Dolberg, 81), Dabbur
Goal: 1-0 Nkunku (28)