Glioblastoma (GBM) is a WHO grade IV brain tumor with dismal prognosis. Although post-surgical radiation chemotherapy combined with temozolomide is the standard line of treatment, GBM cells surviving radiotherapy contribute to tumor progression and recurrence even more aggressively. Researchers have now unveiled the mechanism of radioresistance in GBM cells, identifying therapeutic targets to overcome radioresistance. Moreover, the team has discovered a clinical drug that sensitizes GBM cells to radiotherapy and could replace temozolomide.
