In Reply We appreciate the comments by Dr Jiang and colleagues regarding our recent Research Letter. In our cohort, 5 of 79 patients (6.3%) during the Delta wave and 5 of 33 patients (15.1%) during the Omicron wave received a second dose of the SARS-CoV-2 vaccine at least 2 weeks prior to hospital admission; none of the vaccinated patients were admitted to intensive care units or required treatment with vasopressors. The incidence rate of MIS-C during the Omicron wave was lower than during both the Delta and Alpha waves.
