Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity

by Ina Luiken, Stephan Eisenmann, Jakob Garbe, Hanna Sternby, Robert C. Verdonk, Alexandra Dimova, Povilas Ignatavicius, Lucas Ilzarbe, Peeter Koiva, Anne K. Penttilä, Sara Regnér, Johannes Dober, Walter A. Wohlgemuth, Richard Brill, Patrick Michl, Jonas Rosendahl, Marko Damm

Background

Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable.

Aims

To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients.

Methods

Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed.

Results

358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1–3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05–8.45, p<0.001) and pre-existing CLD (OR = 2.93, 95%CI 1.17–7.32, p = 0.022) as independent predictors of severe AP. Log rank test showed a significantly worse one-year survival in patients with bilateral compared to unilateral PEs in a subgroup.

Conclusions

Increasing awareness of the prognostic impact of large and bilateral PEs and pre-existing CLD could facilitate the identification of patients at high risk for severe AP in the early phase and thus improve their prognosis.