Manchester United and Chelsea need a swift response to their title credentials being damaged by home defeats last weekend, while one or both of Liverpool and Arsenal's perfect records will come to an end when they face off at Anfield on Monday night.
Crystal Palace and Everton also have the chance to claim top spot when they meet at Selhurst Park on Saturday, while the other side with maximum points from the opening two weekends, Leicester, face a daunting trip to Manchester City.
Gareth Bale will not be fit to feature to Tottenham when they host Newcastle on Sunday, but Harry Kane and Son Heung-min are enough for the Magpies to fear after the England captain set up the South Korean to score four at Southampton.
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