In the Original Investigation titled “Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial” published in the October 15, 2019, issue of JAMA, one of the interventions was incompletely described in the Abstract and Methods section. It should have specified that patients received either high-flow nasal oxygen alone or high-flow nasal oxygen alternating with noninvasive ventilation.