A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea – dose optimization, clinical outcomes, and CD4+ T cell responses

by Sunniva Todnem Sakkestad, Hans Steinsland, Steinar Skrede, Kristine Lillebø, Dag Harald Skutlaberg, Anne Berit Guttormsen, Anton Zavialov, Sari Paavilainen, Hanne Søyland, Marianne Sævik, Astrid Rykkje Heien, Marit Gjerde Tellevik, Eileen Barry, Nina Langeland, Halvor Sommerfelt, Kurt Hanevik

Trial registration

ClinicalTrials.gov ClinicalTrials.gov, Project ID: NCT02870751