This Viewpoint highlights the 2 most concerning aspects of the Braidwood Management Inc v Becerra ruling and their potential effect on health equity.
This randomized clinical trial evaluates the effects of Helicobacter pylori stool antigen assessment plus fecal immunochemical testing (FIT), vs FIT alone, on gastric cancer incidence and mortality among adults in Taiwan.
Gastric cancer is a leading cause of cancer death globally. Although endoscopy-based screening has led to a decrease in gastric cancer mortality in Eastern Asian countries with populations at high risk, lack of risk stratification and the cost of health care infrastructure and trained personnel limit its use in most of the world. Availability of noninvasive biomarkers for the identification of high-risk individuals could optimize endoscopy-based screening programs for a more general application,... Читать дальше...
This study assesses mpox-specific immune responses for 12 months after MVA-BN vaccination.
This Viewpoint discusses the new federal regulations that require health care institutions to develop virtual care technologies that are accessible to patients with disabilities.
This randomized clinical trial assesses the effect of a liberal vs a restrictive hemoglobin threshold for red blood cell transfusion on unfavorable neurological outcome in patients with acute brain injury.
Acute neurological injuries, especially traumatic brain injuries and subarachnoid hemorrhages, often affect young and previously healthy patients with years of active life to come. Mortality remains very high following any severe acute brain injury, and importantly, a significant proportion of survivors have long-term sequelae that prevent them from independent living. Despite proliferation of dedicated neurocritical care units and improvements in patient management over past decades, very few interventions clearly improve patient-oriented... Читать дальше...
This review examines the epidemiology, transmission, clinical presentation, assessment and diagnosis, prognosis, management and treatment, and prevention of mpox.
This randomized clinical trial examines whether 3 cycles of carboplatin, etoposide, and vincristine chemotherapy is noninferior to 6 cycles for enucleated unilateral retinoblastoma with high-risk pathological features.
In Reply We thank all correspondents for their attention to our work. Our Review intended to focus on questions most relevant to primary care and other general medical clinicians and gave less attention to questions more relevant to mental health specialty care.
To the Editor The Review by Dr Simon and colleagues on management of depression in adults provides many treatment options for depressive illnesses. However, we were surprised and disappointed that monoamine oxidase inhibitors (MAOIs), a well-established treatment, were not included among the third-line treatment options for nonresponding depression. There are more than 6 decades of data confirming MAOIs’ efficacy in controlled trials and meta-analyses. In addition, MAOIs are included in national... Читать дальше...
Retinoblastoma, a rare but aggressive eye cancer in infants and young children, accounts for 2% to 4% of pediatric malignancies globally, with an incidence rate ranging from 1 in 20 000 to 1 in 15 000 children. Approximately 8000 new cases are reported annually across the globe, of which more than 1000 are reported in China. Notably, regions with the highest prevalence, such as Asia and Africa, have the highest mortality rates, ranging from 40% to 70%, in stark contrast with the 3% to 5% mortality rate in high-income countries. Читать дальше...
When you hear the cancer doctor we just met read the biopsy results from your PET scan, the issues leading up to this moment, directly off an Epic chart with precision, wonder: then
This pooled cross-sectional study explores prescribing rates for glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors among US patients with type 1 diabetes.
This JAMA Insights examines the treatment and rising prevalence of anal cancer in the US in high-risk groups, including people with HIV and immunosuppression associated with solid organ transplant.
This JAMA Patient Page describes allergic rhinitis and its risk factors, diagnosis, and treatment.
In Reply Our study adjusted the FIT cutoff to yield the same overall positivity rate as reported for the mt-sRNA test (17%) to enhance comparability of diagnostic performance of both tests. Below we address each of the 3 points made by Drs Yang and Ma.
To the Editor We read with interest the recent study that compared the fecal immunochemical test (FIT) positivity threshold vs multitarget stool RNA (mt-sRNA) testing for colorectal cancer screening. However, we have concerns regarding the study methodology and the capability of FIT to fully replace the mt-sRNA panel.
Some of the most dramatic chapters in the history of medicine deal with the development of surgery. “A good surgeon must have an eagle’s eye, a lion’s heart, a lady’s hand.” Thus runs the old English proverb, formulated in the days before anesthetics banished pain and antiseptics averted the horrors of wound infection. Today no large part of the body is destined to remain free from surgical approach. The abdomen, thorax and cranium have already been invaded by the trained surgeon with eminent success in the relief of a variety of maladies. Читать дальше...
This JAMA Clinical Guidelines Synopsis summarizes the Wilderness Medical Society’s 2024 recommendations on prevention, diagnosis, and treatment of acute altitude illness.
The Original Investigation titled “Risankizumab for Ulcerative Colitis: Two Randomized Clinical Trials,” published on July 22, 2024, has been updated to fix the affiliation for Nobuo Aoyama and add the names of investigators (Federico Arguelles Arias, Toshiyuki Endo, Jill Gaidos, Jee Hyun Kim, Albert Pirmagomedov, and Nikolaos Viazis) missing from the original version of Supplement 3. This article was corrected online.
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
This Medical News article discusses the reasons behind the resurgence of pertussis in the US and elsewhere this year.
This Medical News article discusses new research on global trends in nearsightedness, possible ways to prevent and treat it, and calls to classify it as a disease.
