Many interesting proteins have flat, featureless surfaces, lacking the deep pockets in which small molecules usually bind. But structures can be deceptive: crevasses can open unexpectedly, revealing “cryptic sites” for ligands. Or not – just because a site is available does not mean it is ligandable (able to bind to ligands with high affinity). A new (open access) paper in Drug Disc. Today by Sandor Vajda and collaborators at Boston University and Stony Brook University asks “which cryptic sites... Читать дальше...
Parka zipper broken? Flannel too boxy? Snowpants too long? Nokomis Tailor’s specialty is altering cold-weather clothing.
The state semifinals and finals in Class 3A, 2A and 1A take place at the downtown stadium Tuesday and Wednesday, with championship matches Friday.
Amid accusations of financial mismanagement, the Neighborhood Safety Department proposed giving the contract to a business previously flagged in a whistleblower complaint about self-dealing.
Our reviewers run their eyes over new fiction and non-fictions release
The Spanish auteur’s first book spans autobiographical essays, short stories and diary essays from his personal archive, including a story he wrote in 1967 about a porn star writing her memoir.
In this year’s shortlist, five of the six books are by women, three authors have been nominated before and there’s one debut novel.
Melanie Cheng’s new novel follows the lives of one family, living in the shadow of grief
Provocative British band Fat White Family, notorious for their chaotic on-stage energy and off-stage antics, are returning to Australia – and hopefully won’t be arrested this time.
This season of 9-1-1 has not been smooth sailing for the Wilson family. After fighting to bring Mara home on 9-1-1 …
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Inflation is finally easing in Norway, but rental rates are literally going through the roof. New figures confirm how they’ve risen by 20 percent just in the past two years, and the average rental rate in Oslo is now nearly NOK 19,000 per month. The situation is similar in Bergen and Stavanger, where the average […]
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Indonesia has banned the iPhone 16 and asked for people to snitch on anyone they see using one: "If you're using an iPhone 16 in Indonesia, it means the device is illegal," said Agus Gumiwang Kartasasmita, the country's Industry Minister. The pretext is that the device lack the International Mobile Equipment Identity (IMEI) certification for use there. — Read the rest
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Labour has prepared the country for a “painful” fiscal event
Chicago Bears cornerback Tyrique Stevenson taunted Commanders fans before the wild Hail Mary play that won Washington the game on Sunday night.
El exentrenador del Barça no tiene pensado dirigir esta temporada... pero si desde Mánchester le llaman... nada es imposible por la dimensión del club inglés Leer
A SMALL train station in the UK has been named the best in the country – beating some of the country’s largest and busiest.
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Today's word is can be used to discuss the weather, religious belief or even as a pet name.
(Telecompaper) Gilat Satellite Networks said the US Department of Defense has awarded the company with another contract worth more than USD 4 million, for Gilat's US-based subsidiary, DataPath...
