The Original Investigation titled “Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial,” published on January 12, 2023, was corrected to fix the Role of Funder/Sponsor statement. The Role of Funder/Sponsor statement should have read “The National Center for Advancing Translational Sciences had a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation... Читать дальше...
In this narrative medicine essay, a gastroenterologist learns of his 34-year-old brother’s stroke in Oslo and struggles to understand how such a young, healthy man could have a stroke while exercising.
In Reply Our study compared the end points of cancer-specific mortality and late-stage cancer in randomized clinical trials of cancer screening. Drs Kim and Gibbs write that the relationship between these could be affected by changes in cancer staging and treatment. We agree that this is true not only for our comparison of end points, but for cancer screening in general. For example, a screening test that is effective at reducing cancer mortality could become ineffective if new treatments decrease differences in survival between stages. Читать дальше...
In Reply We appreciate the comments from Ms Lacasse and colleagues regarding our recently published Viewpoint examining the current landscape of state biomarker testing laws.
To the Editor A recent study provided a robust analysis of the association between the reduction in stage III to IV cancer diagnoses and overall survival gains in historical cancer screening trials, and the accompanying Editorial added an important epidemiological perspective. However, the relationship between cancer stage at diagnosis and survival is not static. Data from the studies examined, many of which were initiated 30 to 40 years ago, are of questionable relevance in the modern era.
To the Editor A recent Viewpoint referenced the American Cancer Society Cancer Action Network’s state-by-state campaign to pass legislation ensuring coverage of biomarker testing. We appreciate the attention to our advocacy campaign but disagree with the conclusion that the effect of these laws “may be limited by their lack of reach and implementation challenges.” Given the patchwork nature of the US health care system, it is often necessary to enact consumer protections on both the federal and state levels. Читать дальше...
(From Our Regular Correspondent)
This Medical News article discusses research that found Black individuals and women are less likely to survive after receiving cardiopulmonary resuscitation for out-of-hospital cardiac arrest than White people or men.
This Medical News story discusses new guidelines for the use of pemivibart, a monoclonal antibody marketed as Pemgarda, as preexposure prophylaxis against COVID-19 in immunocompromised individuals.
Previous studies suggest twice-yearly mass distribution of the antibiotic azithromycin reduces childhood mortality in sub-Saharan Africa. The World Health Organization (WHO) has approved the practice with stipulations limiting distribution to infants aged 1 to 11 months, citing concerns about antimicrobial resistance.
Older adults with chronic kidney failure may not benefit as much from dialysis as expected, according to a study in the Annals of Internal Medicine. Researchers found that although patients may live about a week longer, they spend more time in hospital settings.
An experimental malaria vaccine could offer protection during pregnancy for up to 2 years without a booster dose, according to a randomized clinical trial conducted in Mali. The 3-dose vaccine, known as Plasmodium falciparum sporozoite (PfSPZ) vaccine, had previously been tested successfully in adults in other parts of Africa.
Researchers have suspected that there’s a link between chronic low-grade inflammation and psychiatric disorders. Now, a recent cohort study points to specific inflammatory biomarkers that might be associated with an increased risk of depression, anxiety, and stress-related disorders.
Expanding Medicare coverage of a glucagon-like peptide-1 (GLP-1) receptor agonist to treat obesity could increase annual spending by several billion dollars, a study in Health Affairs found.
A phase 3 clinical trial evaluating the safety and efficacy of a messenger RNA (mRNA) combination vaccine for COVID-19 and influenza had mixed results, the vaccine’s manufacturers announced. The vaccine was a collaboration between BioNTech and Pfizer and was tested among more than 8000 healthy adults aged 18 to 64 years.
The US Food and Drug Administration (FDA) approved the first at-home test for syphilis for sale without a prescription. The test, manufactured by NOWDiagnostic and called First To Know Syphilis Test, arrives amid an 80% increase in cases in the US between 2018 and 2022, from 115 000 to 207 000 cases.
The US government has reached an agreement with drug companies to lower the price of 10 common prescription medications for people who are covered by Medicare Part D, the Department of Health and Human Services (HHS) announced. The 10 drugs cover a range of common conditions, including type 2 diabetes, heart failure, and autoimmune disorders.
Royal Wootton Bassett Town aim to become history-makers on Sunday when they take on Torquay United in the Adobe Women's FA Cup third qualifying round (2pm kick off). Having fallen short at this stage for two consecutive years, a victory will see Bassett reach the competition first round proper for the first time ever. To achieve that feat though Bassett will need to pull of an upset win against tier five opponents. Bassett did just that to see off Ilminster Town on penalties in the previous round. Читать дальше...
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