In Reply Drs Xia and Su raise several queries about our study, the aMAZE trial. First, they state, “The study did not assess left atrial appendage electrical isolation, which is important considering the mechanism of action of the intervention,” implying this affected outcomes. The proposed mechanism of action of LAA ligation as adjunctive therapy to PVI was 2-fold: LAA electrical isolation and left atrial volume (LAV) reduction. LAA ligation results in LAA ischemic necrosis, atrophy, and resorption, analogous to amputation. Читать дальше...
To the Editor A recent Review provided comprehensive information about the manifestations and treatment options for patients with systemic lupus erythematous (SLE). As maternal-fetal medicine subspecialists, we hope to provide additional insight into an obstetrical complication that can arise in patients with SLE during pregnancy and discuss current management recommendations.
To the Editor A recent study investigated the safety and effectiveness of percutaneous left atrial appendage (LAA) ligation with catheter pulmonary vein isolation (PVI) for nonparoxysmal atrial fibrillation (AF). Although the study design and execution were commendable, we have several concerns about its methodology and interpretation. First, the study’s primary outcome measure of freedom from documented atrial arrhythmias at 12 months may not have fully captured the efficacy of percutaneous LAA ligation adjunctive to PVI isolation. Читать дальше...
This Medical News story examines the controversy surrounding the FDA’s first authorization of flavored e-cigarettes, in this case menthol.
This JAMA Insights reviews the health effects of vaping among youth in the US and current recommendations for screening and treatment.
The introduction of electronic cigarettes (e-cigarettes) in recent years has created new dilemmas for clinical and research communities. E-cigarettes are battery-powered devices that heat liquids containing nicotine, flavoring, and other substances to create aerosols. Their use is often called “vaping.” E-cigarettes have been marketed as safer alternatives to cigarettes because they do not contain the carcinogens found in combustible tobacco products. More than 4.5% of US adults, 10% of high school students... Читать дальше...
This Medical News article is an interview with US Surgeon General Vivek Murthy, MD, MBA, and JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, about his call for a warning label on social media platforms.
Children absorb much less nicotine from secondhand e-cigarette vapor than from secondhand tobacco smoke, according to a study of roughly 1800 children in the US aged 3 to 11 years.
The Mediterranean diet, which emphasizes eating more fruits, vegetables, legumes, and healthy fats, has already been associated with health benefits for adults. Now, a systematic review suggests it may have similar effects on children and teens. Researchers analyzed data from 9 randomized clinical trials involving 577 children aged 3 years to 18 years that measured the effects of Mediterranean diet–based interventions on cardiometabolic markers.
In July, the World Health Organization (WHO) prequalified the first hepatitis C virus (HCV) self-test. The product, called OraQuick HCV self-test, is an extension of the OraQuick HCV Rapid Antibody test that the agency prequalified in 2017 for professional use. This self-test kit is designed as a convenient and stigma-free way to reach people who might not otherwise get tested for HCV and therefore go undiagnosed.
Reducing leisure screen time to just a few hours a week could decrease behavioral issues and increase positive social interactions for children and adolescents, according to a randomized trial of 89 families in Denmark. The study, published in JAMA Network Open, included 181 children aged 4 years through 17 years.
A new personalized immunotherapy using engineered white blood cells successfully shrank solid cancerous tumors in some patients, a study published in Nature Medicine found. The results came from a larger ongoing clinical trial and focused on 7 patients with metastatic colorectal cancer who’d already undergone other treatments and were enrolled in the trial from 2018 to 2023.
Roughly 20% of younger siblings of children with autism spectrum disorder (ASD) were later diagnosed themselves, a new study on familial recurrence of autism published in Pediatrics found. For infants with more than 1 older sibling with autism, the likelihood of ASD rose to about 37%.
Given the past decade’s dramatic increase in glucagon-like peptide-1 receptor agonist (GLP-1 RA) use among people with type 2 diabetes, clinicians have raised concerns about whether the drugs, which target reward areas in the brain, could lead to suicidal thoughts.
Certain characteristics of the highly pathogenic avian influenza A(H5N1), or H5N1 bird flu, in dairy cows may make it easier to transmit the virus to other mammals, according to an unedited study in Nature. Specifically, the researchers found that the bovine H5N1 virus can bind to avian and human cell receptors, an anomaly not found in previous H5N1 viruses, the researchers wrote.
Smarting after their 5-1 loss away at Corsham Town, Royal Wootton Bassett Town delivered the perfect response as Sam Collier's side recorded a thumping derby victory of their own by the same score at home against Malmesbury Victoria.
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Date: 09/03/2024
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