by Emeline Barbieux, Georges Potemberg, François-Xavier Stubbe, Audrey Fraikin, Katy Poncin, Angeline Reboul, Thomas Rouma, Amaia Zúñiga-Ripa, Xavier De Bolle, Eric Muraille
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by Neha M. Nataraj, Reyna Garcia Sillas, Beatrice I. Herrmann, Sunny Shin, Igor E. Brodsky
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by Jung Eun Park, Ji-Hye Yun, Weontae Lee, Jung Sup Lee
The bacterium Vibrio vulnificus causes fatal septicemia in humans. Previously, we reported that an extracellular metalloprotease, vEP-45, secreted by V. vulnificus, undergoes self-proteolysis to generate a 34 kDa protease (vEP-34) by losing its C-terminal domain to produce the C-ter100 peptide. Moreover, we revealed that vEP-45 and vEP-34 proteases induce blood coagulation and activate the kallikrein/kinin system. However, the role of... Читать дальше...
by Andrew N. Murtha, Misha I. Kazi, Eileen Y. Kim, Facundo V. Torres, Kelly M. Rosch, Tobias Dörr
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by Kathryn Meldrum, Yvonne Hornby-Turner, Valda Wallace, Sarah G. Russell, Rachel Quigley, Edward Strivens
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by Phillip Awodutire, Michael Kattan, Oladimeji Adeniyi Akadiri
BackgroundOral Squamous Cell Carcinoma is the most prevalent malignancies affecting the oral cavity. Despite progress in studies and treatment options its outlook remains grim with survival prospects greatly affected by demographic and clinical factors. Precisely predicting survival rates and prognosis plays a role in making treatment choices for the best achievable overall health outcomes.
ObjectiveTo develop and... Читать дальше...
by Leandro Junges, Daniel Galvis, Alice Winsor, Grace Treadwell, Caroline Richards, Stefano Seri, Samuel Johnson, John R. Terry, Andrew P. Bagshaw
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by Ekkehard Hiller, Verena Hörz, Reinhard Sting
Corynebacterium pseudotuberculosis (CPS) is an important bacterial animal pathogen. CPS causes chronic, debilitating and currently incurable infectious diseases affecting a wide range of livestock and wild herbivores including camelids worldwide. Belonging to the Corynebacterium diphtheriae complex, this pathogen can also infect humans. The classical characterization of CPS is typically based on the testing of nitrate reductase activity, separating the two biovars Equi and Ovis. Читать дальше...
by Mst. Sumaiya Khatun, Md Shohel Ul Islam, Pollob Shing, Fatema Tuz Zohra, Shuraya Beente Rashid, Shaikh Mizanur Rahman, Md. Abdur Rauf Sarkar
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by Susannah K. Ayre, Elizabeth A. Johnston, Xanthia E. Bourdaniotis, Leah Zajdlewicz, Vanessa L. Beesley, Jason D. Pole, Aaron Hansen, Harry Gasper, Danica Cossio, Gemma Lock, Belinda C. Goodwin
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by Hanin A. Esaifan, Loai M. Saadah, Khawla Abu Hammour, Rana K. Abu Farha
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by Md. Abdur Rafi, Senjuti Semanta, Tasnim Shahriar, Mohammad Jahid Hasan, Md. Golam Hossain
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by Anthony M. Smith, Masindi Ramudzulu, Patrick Munk, Baptiste J. P. Avot, Kerneels C. M. Esterhuyse, Nico van Blerk, Stanford Kwenda, Phuti Sekwadi
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by Slim Ben-Jemaa, Mekki Boussaha, Nathalie Mandonnet, Philippe Bardou, Michel Naves
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by Muluneh Assefa, Azanaw Amare, Mitkie Tigabie, Getu Girmay, Abebaw Setegn, Yenesew Mihret Wondmagegn, Mebratu Tamir, Debaka Belete, Melak Aynalem, Teshome Belachew, Sirak Biset
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by Beatriz Helena Tess, Celina Maria Turchi Martelli, Maria Cecília Goi Porto Alves, Fanny Cortes, Regina Tomie Ivata Bernal, Wayner Vieira de Souza, Expedito José de Albuquerque Luna, Laura da Cunha Rodrigues, Marcia Cavallari Nunes, Fernando de Castro Reinach, Celso Francisco Hernandes Granato, Edgar Gil Rizzatti, Maria Carolina Tostes Pintão
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by Yuta Asada, Kaori Nishio, Kohei Iitsuka, Jun Yaeda
This study aimed to explore the stressors experienced by older patients with stroke in convalescent rehabilitation wards in Japan. Semi-structured interviews were conducted with four stroke patients aged > 65 years who experienced a stroke for the first time in their lives. The interviews were analyzed using the Steps for Coding and Theorization method for qualitative data analysis. The results of the qualitative analysis demonstrated that patients experienced specific stressors... Читать дальше...
by Paulo Moreira Bogossian, Juliana Santos Pereira, Nathalia Felicio da Silva, Ayrton Rodrigo Hilgert, Sarah Raphaela Torquato Seidel, Joice Fülber, Carla Bargi Belli, Wilson Roberto Fernandes
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by Stefanie Katharina Frenzer, Leonie Feuer, Alexander Bartel, Astrid Bethe, Antina Lübke-Becker, Babette Klein, Wolfgang Bäumer, Roswitha Merle
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by Natália O. Alves, Jéssica A. Oshiro, Yunna C. Silva, Gabriela C. Pacher, Aline E. Casaril, Yasmin S. Rizk, Silvia N. O. Uehara, Anamaria M. M. Paniago, Isadora L. X. Andrade, Carla C. P. Arruda, Alessandra G. Oliveira
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by Zhengyang Guo, Shimin Wang, Yang Wang, Zi Wang, Guangshuo Ou
Chemical mutagenesis-driven forward genetic screens are pivotal in unveiling gene functions, yet identifying causal mutations behind phenotypes remains laborious, hindering their high-throughput application. Here, we reveal a non-uniform mutation rate caused by Ethyl Methane Sulfonate (EMS) mutagenesis in the C. elegans genome, indicating that mutation frequency is influenced by proximate sequence context and chromatin status. Читать дальше...
by J. Ian Hertzler, Jiajing Teng, Annabelle R. Bernard, Michelle C. Stone, Hannah L. Kline, Gibarni Mahata, Nitish Kumar, Melissa M. Rolls
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by Anubha Dey, Suresh Mudunuri, Manjari Kiran
Synthetic lethality (SL) and synthetic viability (SV) are commonly studied genetic interactions in the targeted therapy approach in cancer. In SL, inhibiting either of the genes does not affect the cancer cell survival, but inhibiting both leads to a lethal phenotype. In SV, inhibiting the vulnerable gene makes the cancer cell sick; inhibiting the partner gene rescues and promotes cell viability. Many low and high-throughput experimental approaches have been employed to identify SLs and SVs... Читать дальше...
by Easwaran Ramamurthy, Snigdha Agarwal, Noelle Toong, Heather Sestili, Irene M. Kaplow, Ziheng Chen, BaDoi Phan, Andreas R. Pfenning
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by Efrat Cohen-Davidi, Isana Veksler-Lublinsky
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In animals, this regulation is achieved via base-pairing with partially complementary sequences on mainly 3’ UTR region of messenger RNAs (mRNAs). Computational approaches that predict miRNA target interactions (MTIs) facilitate the process of narrowing down potential targets for experimental validation. The availability of new datasets of high-throughput... Читать дальше...