by Shaonil Binti, Adison G. Linder, Philip T. Edeen, David S. Fay
Protein tyrosine phosphatases non-receptor type (PTPNs) have been studied extensively in the context of the adaptive immune system; however, their roles beyond immunoregulation are less well explored. Here we identify novel functions for the conserved C. elegans phosphatase PTPN-22, establishing its role in nematode molting, cell adhesion, and cytoskeletal regulation. Through a non-biased genetic screen, we found that loss... Читать дальше...
by Lucas Rudelt, Daniel González Marx, F. Paul Spitzner, Benjamin Cramer, Johannes Zierenberg, Viola Priesemann
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by Lin Yuan, Ling Zhao, Jinling Lai, Yufeng Jiang, Qinhu Zhang, Zhen Shen, Chun-Hou Zheng, De-Shuang Huang
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by Tom E. Hardwicke, Sarah R. Schiavone, Beth Clarke, Simine Vazire
Research articles published by the journal eLife are accompanied by short evaluation statements that use phrases from a prescribed vocabulary to evaluate research on 2 dimensions: importance and strength of support. Intuitively, the prescribed phrases appear to be highly synonymous (e.g., important/valuable, compelling/convincing) and the vocabulary’s ordinal structure may not be obvious to readers. We conducted an online... Читать дальше...
by Weichen Zhou, Kalpita R. Karan, Wenjin Gu, Hans-Ulrich Klein, Gabriel Sturm, Philip L. De Jager, David A. Bennett, Michio Hirano, Martin Picard, Ryan E. Mills
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by Zonglai Liang, Daniel Christiaan Dondorp, Marios Chatzigeorgiou
During embryonic development, tissues and organs are gradually shaped into their functional morphologies through a series of spatiotemporally tightly orchestrated cell behaviors. A highly conserved organ shape across metazoans is the epithelial tube. Tube morphogenesis is a complex multistep process of carefully choreographed cell behaviors such as convergent extension, cell elongation, and lumen formation. The identity of... Читать дальше...Kareem Elgazzar/The Enquirer / USA TODAY NETWORK
I’m still sad that we never saw Joey Votto as a Mariner in those final couple of years.
Читать дальше...Cary Edmondson-USA TODAY Sports
MLB news roundup
Good morning A’s fans! Time to rise and shine.
The A’s fell to the Tampa Bay Rays in last night’s contest, though since it’s a four-game series the club still has a chance at splitting the series. It wasn’t all bad in the close 4-2 loss as Rule 5 rookie Mitch Spence set a career-high in strikeouts, JJ Bleday hit his 17th home run, and we also got a successful MLB debut from the last remaining piece of the Chris Bassitt trade. Читать дальше...
Andy Abeyta/The Desert Sun / USA TODAY NETWORK
The Royals are hot
Читать дальше...Ancora, which owns a 4 percent stake in Forward, stated the case to the company's board that it would function better in the private market.
The new flagship G700 becomes the third intercontinental jet in the Amazon founder's hangar, if reports are correct, with a regional jet thrown in for short hops.
Steps for using GSC to review your traffic, analyze the search landscape and make impactful optimizations for quick results.
"Squid sucker teeth have some outstanding properties."
As with EVs, digital money was a niche product for years before gaining widespread acceptance. Now, digital blockchain-based monies might be on the verge of a major breakthrough.
by Pargev Hovhannisyan, Kathrin Stelzner, Markus Keicher, Kerstin Paprotka, Mastura Neyazi, Mindaugas Pauzuolis, Waled Mohammed Ali, Karthika Rajeeve, Sina Bartfeld, Thomas Rudel
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by Luz E. Cabrera, Suvi T. Jokiranta, Sanna Mäki, Simo Miettinen, Ravi Kant, Lauri Kareinen, Tarja Sironen, Jukka-Pekka Pietilä, Anu Kantele, Eliisa Kekäläinen, Hanna Lindgren, Pirkko Mattila, Anja Kipar, Olli Vapalahti, Tomas Strandin
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by Fumika Mi-ichi, Hiroshi Tsugawa, Tam Kha Vo, Yuto Kurizaki, Hiroki Yoshida, Makoto Arita
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by Elsie H. Shogren, Jason M. Sardell, Christina A. Muirhead, Emiliano Martí, Elizabeth A. Cooper, Robert G. Moyle, Daven C. Presgraves, J. Albert C. Uy
Читать дальше...HTC, the maker of the HTC Vive virtual reality headsets, said its Viverse platform has created a no-code virtual world builder.
Mark Hamill has opened up about how Carrie Fisher's December 2016 death affected the "heart" of the Star Wars franchise.
You cannot protect people from harm if part of what you offer them is a different kind of harm.
Brain scan study hints that methods could be developed to detect the earliest stages of neurodegenerative disease
Your webcam turns on for no reason. Why? The idea that some unknown eyeball might be watching you might make you nervous. It did me — which is why I’m telling you how to solve that problem.
Читать дальше...When a skyscraper-sized asteroid narrowly misses Earth in 2029, three spacecraft may be along for the ride.
By Jesse Published: August 22nd, 2024