In this issue of JAMA, Deschamps and colleagues report results of the Electroencephalographic Guidance of Anesthesia to Alleviate Geriatric Syndromes-Canada (ENGAGES-Canada) trial. ENGAGES-Canada compared rates of postoperative delirium among 1140 patients 60 years or older undergoing cardiac surgery who were randomly assigned to 1 of 2 strategies to prevent excessive dosing of inhaled general anesthetics: electroencephalogram (EEG)-guided dosing vs usual care, in which anesthesia dose was guided... Читать дальше...
A defining characteristic of poetry is its ability to express what might seem to defy words. Hence its indispensability in the medical realm, where clinicians and patients alike so often encounter such ineffable moments as the birth of a child, the end of life, or, as in “Radiance,” the uncertainties of a cancer diagnosis. The poem brilliantly intermingles the wonder of medical technologies that allow us to see inside our bodies with the faith that for many illuminates our inner selves. Juxtaposition works here in several additional ways... Читать дальше...
In Reply In the AGENT IDE trial, treatment of in-stent restenosis with a coronary paclitaxel-coated balloon significantly reduced the rate of the primary end point of 1-year target lesion failure compared with conventional balloon angioplasty. Among the components of the primary end point, target lesion revascularization was required to be adjudicated as ischemia-driven by an independent clinical events committee. Absolute rates of this end point may potentially be influenced by operator practice patterns; however... Читать дальше...
To the Editor We write to express our concern with the conclusion of the AGENT IDE (A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis) study, which reported drug-coated balloons to be superior to uncoated balloons based on a composite end point of 1-year target lesion failure—defined as the composite of ischemia-driven target lesion revascularization, target vessel–related myocardial infarction, or cardiac death. This... Читать дальше...
This JAMA Guide to Statistics and Methods article explains the test-negative study design, an observational study design routinely used to estimate vaccine effectiveness, and examines its use in a study that estimated the performance of messenger RNA boosters against the Omicron variant.
In the Original Investigation titled “Identifying Children Likely to Benefit From Antibiotics for Acute Sinusitis: A Randomized Clinical Trial,” published on July 25, 2023, a Conflict of Interest Disclosure was mistakenly included. The disclosure for Dr Shaikh has been removed. This article was corrected online.
This Viewpoint discusses ways to ensure the proficiency of bilingual communication among health care staff in patient-clinician encounters, such as language testing and use of professional interpreters.
In this narrative medicine essay, when a physician’s mother begins experiencing postmenopausal bleeding, the author wonders what it would be like to hear someone’s signs and symptoms and not automatically begin to build a differential.
This study evaluates the association between cost sharing and naloxone prescription abandonment (nondispensing of naloxone prescriptions) in commercial insurance and Medicare plans.
This cross-sectional study examines trends in naloxone dispensing by US retail pharmacies from 2019 to 2023, including prescriber specialty and product brand.
If persons who are engaged in the promotion of preventive medicine ever waver in their faith that progress will attend the effort, their courage and persistence should be further sustained by the recent records of the continued campaigns against yellow fever. The success of Gorgas in eradicating this disease by mosquito control in Havana, in Cuba and in the Panama Canal Zone, has been widely proclaimed as an outstanding, monumental achievement of modern hygiene and sanitation. Less known, though similarly gratifying... Читать дальше...
Since the turn of this century, fatal drug overdoses involving opioids have continued to mount. Despite rhetorical assertions to the contrary, too little investment has been made in the science-based responses to this crisis and progress has been stymied by systems-level factors.
In the Research Letter titled “Global Production of Active Pharmaceutical Ingredients for US Generic Drugs Experiencing Shortages,” published online April 29, 2024, and in print on May 28, 2024, in Table 2, the number and percentage of facilities with and without active pharmaceutical ingredient shortages in Spain were changed to 15 (5.5%) and 12 (4.1%), respectively; in Germany, to 9 (3.3%) and 14 (4.8%), respectively; in Japan, to 7 (2.6%) and 14 (4.8%), respectively; and in France, to 8 (2.9%) and 13 (4.4%)... Читать дальше...
This Medical News story discusses the multiple factors contributing to the resurgence of syphilis in the US.
A recent review of 38 studies found considerable differences among 6 major definitions of post–COVID-19 condition, also known as long COVID, underscoring the “innovative yet fragmented nature of long COVID care models and the critical need for a standardized definition to effectively identify affected patients and evaluate treatment models,” the authors of a linked editorial wrote in Annals of Internal Medicine.
Despite experiencing symptoms, roughly 70% of people with chronic obstructive pulmonary disease (COPD) and asthma do not know they have the condition. They also tend to have worse quality of life and spend more time in the clinic and hospital than those who are healthier.
More than half of older American Indian people had cognitive impairment, up to 3 times the prevalence of cognitive impairment among White people in the US, according to results from a population-based cohort study of almost 400 participants. About 35% of American Indian participants had mild cognitive impairment specifically, the researchers reported in Alzheimer & Dementia. The results were based on data collected from participants aged 70 to 95 years from 11 American Indian tribes.
Taking a fish oil supplement regularly was linked with an increased risk of atrial fibrillation and stroke among people without cardiovascular disease by about 13% and 5%, respectively, a new study reported in BMJ Medicine found.
People who attended ninth grade in Finland with more than 1 peer who had been diagnosed with a mental disorder were 5% more likely to later receive a mental disorder diagnosis themselves compared with those with 1 or no classmates who’d been diagnosed, according to data from a population-based study involving more than 713 800 participants. The researchers enrolled participants when they were about 16 years old and followed them until they were either diagnosed with a mental health condition, left the country, or died.
Current guidelines recommend that people with endometriosis use hormone therapies such as a combined oral contraceptive pill (COCP) or progestogens to manage pain associated with the condition. Now, new research published in The BMJ suggests that progestogen might be a better choice than COCPs for people seeking to minimize pain as well as lower their need for future surgeries.
A rare tumor syndrome—BRCA1-associated protein (BAP1) tumor predisposition syndrome—might be associated with a benign nail condition known as onychopapilloma, according to data from 47 participants aged 13 to 72 years from 35 families who all carried pathogenic variants of BAP1. About 87% of participants with BAP1 tumor predisposition syndrome had nail changes, such as nail splitting and splinter hemorrhages, including many that were consistent with onychopapilloma.
People who kept track of their daily activity levels by monitoring their step counts tended to lower their chance of dying by an amount similar to those who monitored the number of minutes they spent exercising, a new study published in JAMA Internal Medicine found. The results were based on data from about 14 400 US women aged 62 years or older.
After nearly 40 years, the American Academy of Pediatrics (AAP) is now recommending that pediatricians be ready to support people with HIV who want to breastfeed, provided they meet certain criteria, according to a recent clinical report in Pediatrics. The criteria include starting antiretroviral therapy (ART) before or early in pregnancy, maintaining viral suppression, and being committed to taking ART while breastfeeding.
Date: 07/09/2024
Player: Dylan Wells (G)
From: Tucson Roadrunners
To: Tucson Roadrunners
Source: You need a free account to view Transfer URL Sign In/Up
