by Shaked Bergman, Tamir Tuller
CRISPR is a gene editing technology which enables precise in-vivo genome editing; but its potential is hampered by its relatively low specificity and sensitivity. Improving CRISPR’s on-target and off-target effects requires a better understanding of its mechanism and determinants. Here we demonstrate, for the first time, the chromosomal 3D spatial structure’s association with CRISPR’s cleavage efficiency, and its predictive capabilities. We used high-resolution... Читать дальше...
by Tyson L. Hedrick
Much has been written about the energetic effects of animals moving in schools or flocks, but experimental results are few and often ambiguous. A new study in PLOS Biology shows that schooling greatly reduces the cost of transport for fish in turbulent flow. Much has been written about the energetic effects of animals moving in schools or flocks, but experimental results are few and often ambiguous. This Primer explores a new study in PLOS Biology which shows that schooling... Читать дальше...Jacqueline Williams, who plays the Atticus Finch's Black housemaid Calpurnia, says Sorkin's play adaptation of "To Kill a Mockingbird" gives more space to Black voices like her character's.
by Michael J. Asmussen, Erica Casto E., Martin J. MacInnis, Benno M. Nigg
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by Yichen Wang, Furong Zhong, Fengyun Xiao, Junjie Li, Xiaosong Liu, Guoying Ni, Tianfang Wang, Wei Zhang
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by Hanghao Ma, Yan Chen
BackgroundThe causal relationship between sex hormone-binding globulin (SHBG) and infertility has remained unclear. Thus, we used Mendelian randomization (MR) to investigate this relationship.
MethodsRisk factors for SHBG were extracted from European individuals within the UK Biobank using single-nucleotide polymorphism (SNP) data. Summary-level data for infertility outcomes were obtained from the FinnGen dataset. The causal relationship between SHBG and... Читать дальше...
by Sarah Sewaralthahab, Lujain A. Alsubki, Maram S. Alhrabi, Abdulrahman Alsultan
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by Jiajia Yao, Wanli Huang, Lixia Gao, Yan Liu, Qi Zhang, Juncai He, Li Zhang
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by Yuxuan Xiao, Will W. Qiang, Chung-Shing Chan, Steve H. L. Yim, Harry F. Lee
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by Tomasz Zaprutko, Julia Cynar, Maria Sygit, Aleksandra Stolecka, Patrycja Skorupska, Paulina Jaszcz, Dorota Kopciuch, Anna Paczkowska, Piotr Ratajczak, Krzysztof Kus
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by Yibo Han, Yong Wang, Shuo Li, Kohji Sato, Satoru Yamagishi
Craniopharyngiomas are rare tumors of the central nervous system that typically present with symptoms such as headache and visual impairment, and those reflecting endocrine abnormalities, which seriously affect the quality of life of patients. Patients with craniopharyngiomas are at higher cardiometabolic risk, defined as conditions favoring the development of type 2 diabetes and cardiovascular disease. However, the underlying... Читать дальше...
by Shudong Yang, Beijun Zhou, Jiaxuan Mo, Ruidi He, Kunbo Mei, Zhi Zeng, Gaigai Yang, Yuwei Chen, Mingjiang Luo, Siliang Tang, Zhihong Xiao
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by Leon Mendel McClusky, Julius Nielsen, Jørgen Schou Christiansen
Cystic spermatogenesis in the subadult, maturing and adult Greenland shark (Somniosus microcephalus) displays multiple novel features, characterized early on by an unorganized internal cellular environment of the spermatocysts (anatomically discrete follicle-like units containing a single germ cell stage and its complement of co-developing Sertoli cells). These typically show polar asymmetries due to asymmetrically distributed germ and Sertoli cells. Читать дальше...
by Chaloempon Sritong, Weerachon Sawangproh, Teerapong Teangsompong
As the metaverse emerges as a transformative digital realm, its adoption and integration into various aspects of society are subjects of increasing scholarly and practical interest. This research investigated the factors influencing the intention to use metaverse technology (IU) in Bangkok metropolitan areas, with a particular focus on the extended Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) framework, alongside... Читать дальше...
by Francisco Beron-Vera, Sergio A. Lemus, Ahmed O. Mahmoud, Pedro Beron-Vera, Alexander Ezzy, Cheng-Bang Chen, Bryan J. Mann, Francesco Travascio
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by Carole Bandiera, Evelina Cardoso, Isabella Locatelli, Khalil Zaman, Antonella Diciolla, Antonia Digklia, Athina Stravodimou, Valérie Cristina, Veronica Aedo-Lopez, Ana Dolcan, Apostolos Sarivalasis, Hasna Bouchaab, Jérôme Pasquier, Jennifer Dotta-Celio, Solange Peters, Dorothea Wagner, Chantal Csajka, Marie Paule Schneider
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by SuWen Li, YanNan Huang, HongYin Xie
BackgroundThe recommendation for Chlorhexidine (CHX) as a traditional oral care solution is decreasing, and herbal oral care products are being considered as a potential alternative. This network meta-analysis aims to determine if herbal oral care products for oral care in mechanically ventilated patients are superior to CHX and provide direction for future research by comparing the effectiveness of herbal oral care products currently available.
... Читать дальше...
by Ruyi Zhang, Shanshan Li, Kelly Schippers, Boaz Eimers, Jiahui Niu, Bastian V. H. Hornung, Mirjam C. G. N. van den Hout, Wilfred F. J. van Ijcken, Maikel P. Peppelenbosch, Ron Smits
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by Abdulmalik A. Oladipupo, Kevin R. Stuart, Timothy J. Bruce, Mark A. Drawbridge, D. Allen Davis
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by Ivan Ahimbisibwe, Cathbert Tumusiime, Laban Muteebwa, Ezekiel Mupere, Irene Andia Biraro
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by Eileen A. Lacey, Shannon L. O’Brien, Pablo A. Cuello, Mauro N. Tammone
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by Elle R. Marcus, Jossie A. Carreras Tartak, Helena Halasz, David Chen, Jarone Lee, Shuhan He
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by Hiten J. Gutka, Jasper Marc G. Bondoc, Ryan Patwell, Shahebraj Khan, Edyta M. Grzelak, Rajendra Goswami, Martin I. Voskuil, Farahnaz Movahedzadeh
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by Naomasa Okimoto, Masanori Ishida, Wataru Gonoi, Kotaro Fujimoto, Keisuke Nyunoya, Mariko Kurokawa, Go Shirota, Hiroyuki Abe, Tetsuo Ushiku, Osamu Abe
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by Sonisha Neupane, Jan Skerswetat, Peter J. Bex
PurposeStereopsis is a critical visual function, however clinical stereotests are time-consuming, coarse in resolution, suffer memorization artifacts, poor repeatability, and low agreement with other tests. Foraging Interactive D-prime (FInD) Stereo and Angular Indication Measurement (AIM) Stereo were designed to address these problems. Here, their performance was compared with 2-Alternative-Forced-Choice (2-AFC) paradigms (FInD Stereo only)... Читать дальше...