by Eun Young Kim, Young Jae Kim, Won-Jun Choi, Ji Soo Jeon, Moon Young Kim, Dong Hyun Oh, Kwang Nam Jin, Young Jun Cho
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by Thi-Thuy-Nga Tran, Que-Huong Tran, Quoc-Thai Nguyen, Minh-Tri Le, Dieu-Thuong Thi Trinh, Khac-Minh Thai
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by Dimitri Chaussard, Florian Bloch, Arpiné Ardzivian Elnar, Yinka Zevering, Jean-Charles Vermion, Rémi Moskwa, Jean-Marc Perone
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by Abdul Rahman Taha, Mustafa Shehadeh, Ali Alshehhi, Tariq Altamimi, Emma Housser, Mecit Can Emre Simsekler, Buthaina Alfalasi, Shammah Al Memari, Farida Al Hosani, Yousif Al Zaabi, Shereena Almazroui, Hamed Alhashemi, Noora Alhajri
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by Marlène Chiarello, Mark McCauley, Sébastien Villéger, Colin R. Jackson
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by Rossella Valentino, Vittoria D’Esposito, Federica Passaretti, Antonietta Liotti, Serena Cabaro, Michele Longo, Giuseppe Perruolo, Francesco Oriente, Francesco Beguinot, Pietro Formisano
by Ao Yu, J. Trevor. Vannatta, Stephanie O. Gutierrez, Dennis J. Minchella
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by Bright K. Ocansey, Chris Kosmidis, Martin Agyei, Améyo M. Dorkenoo, Olusola O. Ayanlowo, Rita O. Oladele, Tchin Darre, David W. Denning
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by Luz Yadira Bravo-Gallego, Laura Francisco-González, Álvaro Vázquez-Pérez, Milagros García-López Hortelano, Rogelio López Vélez, Luis Ignacio González-Granado, Mar Santos, Cristina Epalza, Ana Belén Jiménez, María José Cilleruelo, Sara Guillén, Tania Fernández, Iciar Olabarrieta, María Flores-Chavez, José Tomás Ramos Amador, María Isabel González-Tomé
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by Parul Johri, Wolfgang Stephan, Jeffrey D. Jensen
The ability to accurately identify and quantify genetic signatures associated with soft selective sweeps based on patterns of nucleotide variation has remained controversial. We here provide counter viewpoints to recent publications in PLOS Genetics that have argued not only for the statistical identifiability of soft selective sweeps, but also for their pervasive evolutionary role in both Drosophila and HIV populations. We present evidence... Читать дальше...
by Jack S. Gisby, Marco Catoni
Pack-TYPE transposable elements (TEs) are a group of non-autonomous DNA transposons found in plants. These elements can efficiently capture and shuffle coding DNA across the host genome, accelerating the evolution of genes. Despite their relevance for plant genome plasticity, the detection and study of Pack-TYPE TEs are challenging due to the high similarity these elements have with genes. Here, we produced an automated annotation pipeline designed to study... Читать дальше...
by Emily L. Starke, Keelan Zius, Scott A. Barbee
Fragile X Syndrome (FXS) is the most prevalent cause of inherited mental deficiency and is the most common monogenetic cause of autism spectral disorder (ASD). Here, we demonstrate that disease-causing missense mutations in the conserved K homology (KH) RNA binding domains (RBDs) of FMRP cause defects in its ability to form RNA transport granules in neurons. Using molecular, genetic, and imaging approaches in the Drosophila FXS model system... Читать дальше...
by Rym Ben Boubaker, Asma Tiss, Daniel Henrion, Hajer Guissouma, Marie Chabbert
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by Mathieu Desroches, John Rinzel, Serafim Rodrigues
Bursting is one of the fundamental rhythms that excitable cells can generate either in response to incoming stimuli or intrinsically. It has been a topic of intense research in computational biology for several decades. The classification of bursting oscillations in excitable systems has been the subject of active research since the early 1980s and is still ongoing. As a by-product, it establishes analytical and numerical foundations for... Читать дальше...
by Mark Baillie, Saskia le Cessie, Carsten Oliver Schmidt, Lara Lusa, Marianne Huebner, for the Topic Group “Initial Data Analysis” of the STRATOS Initiative
by Ying Liu, Ruihui Li, Jiawei Luo, Zhaolei Zhang
Precise identification of target sites of RNA-binding proteins (RBP) is important to understand their biochemical and cellular functions. A large amount of experimental data is generated by in vivo and in vitro approaches. The binding preferences determined from these platforms share similar patterns but there are discernable differences between these datasets. Computational methods trained on one dataset do not always work well on another dataset. Читать дальше...
by Katherine E. Overman, Daniel M. Choi, Kawai Leung, Joshua W. Shaevitz, Gordon J. Berman
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by Santhosh Sankar, Nagasuma Chandra
Studying similarities in protein molecules has become a fundamental activity in much of biology and biomedical research, for which methods such as multiple sequence alignments are widely used. Most methods available for such comparisons cater to studying proteins which have clearly recognizable evolutionary relationships but not to proteins that recognize the same or similar ligands but do not share similarities in their sequence or structural folds. In many cases... Читать дальше...
by Jun Feng Lu, Meng Qing Zhu, Bao Cai Xie, Xiao Chen Shi, Huan Liu, Rui Xin Zhang, Bo Xia, Jiang Wei Wu
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