by Jee Hee Yoon, Min Ji Jeon, Mijin Kim, A. Ram Hong, Hee Kyung Kim, Dong Yeob Shin, Bo Hyun Kim, Won Bae Kim, Young Kee Shong, Ho-Cheol Kang
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by Alberto Alonso-Fernández, Nuria Toledo-Pons, Borja G. Cosío, Aina Millán, Néstor Calvo, Luisa Ramón, Sara Hermoso de Mendoza, Daniel Morell-García, Josep Miquel Bauça-Rossello, Belén Núñez, Jaume Pons, Juan A. Palmer, Luisa Martín, María Peñaranda, Joan A. Pou, Jaume Sauleda, Ernest Sala-Llinas
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by Alyssa R. Martin, Aida Sivro, Zoe R. Packman, Eshan U. Patel, Livia R. Goes, Lyle R. McKinnon, Jacquie Astemborski, Gregory D. Kirk, Shruti H. Mehta, Claudia Cicala, James Arthos, Andrew D. Redd, Thomas C. Quinn
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by Natasha N. Gebhart, Richard W. Hardy, Kevin J. Sokoloski
The identification of host / pathogen interactions is essential to both understanding the molecular biology of infection and developing rational intervention strategies to overcome disease. Alphaviruses, such as Sindbis virus, Chikungunya virus, and Venezuelan Equine Encephalitis virus are medically relevant positive-sense RNA viruses. As such, they must interface with the host machinery to complete their infectious lifecycles. Nonetheless... Читать дальше...
by The PLOS ONE Editors
by Ramesh B. Kasetti, Pinkal D. Patel, Prabhavathi Maddineni, Gulab S. Zode
by Khalid Bashir, Inaamul Haq, S. Muhammad Salim Khan, Mariya Amin Qurieshi
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by Jennifer S. Lord, Rachel S. Lea, Fiona K. Allan, Mechtilda Byamungu, David R. Hall, Jessica Lingley, Furaha Mramba, Edith Paxton, Glyn A. Vale, John W. Hargrove, Liam J. Morrison, Stephen J. Torr, Harriet K. Auty
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by Miho Sassa, Evans A. Chadeka, Ngetich B. Cheruiyot, Mio Tanaka, Taeko Moriyasu, Satoshi Kaneko, Sammy M. Njenga, Sharon E. Cox, Shinjiro Hamano
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by Edy F. Pereira, Gregory Gegembauer, Marilene R. Chang, Zoilo P. de Camargo, Thiago F. Nunes, Sergio M. Ribeiro, Lídia R. de Carvalho, Bianca M. Maldonado, Rinaldo P. Mendes, Anamaria M. M. Paniago
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by Habtye Bisetegn, Ayalew Jejaw Zeleke, Endalamaw Gadisa, Girma Shumie, Demekech Damte, Tiruework Fenta, Sinkinesh Behaksra, Abebe Genetu Bayih
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by Andrew Lawson, R Boaz III, A. Corberán-Vallet, Marcos Arezo, Edmundo Larrieu, Marco A. Vigilato, Victor J. Del Rio Vilas
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by Jihène Bettaieb, Amine Toumi, Wissem Ghawar, Sadok Chlif, Mariem Nouira, Nabil Belhaj-Hamida, Adel Gharbi, Nissaf Ben-Alaya, Dhafer Laouini, Hechmi Louzir, Koussay Dellagi, Afif Ben Salah
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by Lilani Karunanayake, Chandika D. Gamage, Chandima P. Gunasekara, Sajiv De Silva, Hidemasa Izumiya, Masatomo Morita, Devinda S. Muthusinghe, Kumiko Yoshimatsu, Roshan Niloofa, Panduka Karunanayake, Wimalasiri Uluwattage, Makoto Ohnishi, Nobuo Koizumi
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by Jing Chen, Jonas Bacelis, Pol Sole-Navais, Amit Srivastava, Julius Juodakis, Amy Rouse, Mikko Hallman, Kari Teramo, Mads Melbye, Bjarke Feenstra, Rachel M. Freathy, George Davey Smith, Deborah A. Lawlor, Jeffrey C. Murray, Scott M. Williams, Bo Jacobsson, Louis J. Muglia, Ge Zhang
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by Thareendra De Zoysa, Eric M. Phizicky
All tRNAs are extensively modified, and modification deficiency often results in growth defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders in humans. In S. cerevisiae, lack of any of several tRNA body modifications results in rapid tRNA decay (RTD) of certain mature tRNAs by the 5’-3’ exonucleases Rat1 and Xrn1. As tRNA quality control decay mechanisms are not extensively studied in other eukaryotes, we studied... Читать дальше...
by Shelbi L. Russell, Evan Pepper-Tunick, Jesper Svedberg, Ashley Byrne, Jennie Ruelas Castillo, Christopher Vollmers, Roxanne A. Beinart, Russell Corbett-Detig
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by Brian Onken, Natallia Kalinava, Monica Driscoll
High glucose diets are unhealthy, although the mechanisms by which ikelevated glucose is harmful to whole animal physiology are not well understood. In Caenorhabditis elegans, high glucose shortens lifespan, while chemically inflicted glucose restriction promotes longevity. We investigated the impact of glucose metabolism on aging quality (maintained locomotory capacity and median lifespan) and found that, in addition to shortening lifespan... Читать дальше...
by Yizhuo Zhou, Pedro N. Pozo, Seeun Oh, Haley M. Stone, Jeanette Gowen Cook
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by Leandro José de Assis, Lilian Pereira Silva, Li Liu, Kerstin Schmitt, Oliver Valerius, Gerhard H. Braus, Laure Nicolas Annick Ries, Gustavo Henrique Goldman
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by Lucia Simonicova, W. Scott Moye-Rowley
Azole drugs are the most frequently used antifungal agents. The pathogenic yeast Candida glabrata acquires resistance to azole drugs via single amino acid substitution mutations eliciting a gain-of-function (GOF) hyperactive phenotype in the Pdr1 transcription factor. These GOF mutants constitutively drive high transcription of target genes such as the ATP-binding cassette transporter-encoding CDR1 locus. Previous characterization of Pdr1 has demonstrated... Читать дальше...
by Claudia Bachmann, Tom Tetzlaff, Renato Duarte, Abigail Morrison
The impairment of cognitive function in Alzheimer’s disease is clearly correlated to synapse loss. However, the mechanisms underlying this correlation are only poorly understood. Here, we investigate how the loss of excitatory synapses in sparsely connected random networks of spiking excitatory and inhibitory neurons alters their dynamical characteristics. Beyond the effects on the activity statistics, we find that the loss... Читать дальше...
by Thiago S. Guzella, Vasco M. Barreto, Jorge Carneiro
Phenotypic variation in the copy number of gene products expressed by cells or tissues has been the focus of intense investigation. To what extent the observed differences in cellular expression levels are persistent or transient is an intriguing question. Here, we develop a quantitative framework that resolves the expression variation into stable and unstable components. The difference between the expression means in two cohorts isolated... Читать дальше...
by Kavita Agarwal, Lloyd S. Robinson, Somya Aggarwal, Lynne R. Foster, Ariel Hernandez-Leyva, Hueylie Lin, Brett A. Tortelli, Valerie P. O’Brien, Liza Miller, Andrew L. Kau, Hilary Reno, Nicole M. Gilbert, Warren G. Lewis, Amanda L. Lewis
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Note: The writer of this review watched The Personal History Of David Copperfield from home on a digital screener. Before making the decision to see it—or any other film—in a movie theater, please consider the health risks involved. Click here for an interview on the matter with scientific experts.
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