by Yangqing Deng, Wei Pan
Transcriptome-wide association studies (TWAS and PrediXcan) have been increasingly applied to detect associations between genetically predicted gene expressions and GWAS traits, which may suggest, however do not completely determine, causal genes for GWAS traits, due to the likely violation of their imposed strong assumptions for causal inference. Testing colocalization moves it closer to establishing causal relationships: if a GWAS trait and a gene’s expression share the same associated SNP... Читать дальше...
by Neythen J. Treloar, Alex J. H. Fedorec, Brian Ingalls, Chris P. Barnes
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by Pablo Rodríguez-Sínchez, Egbert H. Van Nes, Marten Scheffer
Stability landscapes are useful for understanding the properties of dynamical systems. These landscapes can be calculated from the system’s dynamical equations using the physical concept of scalar potential. Unfortunately, it is well known that for most systems with two or more state variables such potentials do not exist. Here we use an analogy with art to provide an accessible explanation of why this happens and briefly review some of the possible alternatives. Читать дальше...
by Augusto Anguita-Ruiz, Alberto Segura-Delgado, Rafael Alcalá, Concepción M. Aguilera, Jesús Alcalá-Fdez
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by Loïc Marrec, Anne-Florence Bitbol
The evolution of antimicrobial resistance can be strongly affected by variations of antimicrobial concentration. Here, we study the impact of periodic alternations of absence and presence of antimicrobial on resistance evolution in a microbial population, using a stochastic model that includes variations of both population composition and size, and fully incorporates stochastic population extinctions. We show that fast alternations of presence and absence... Читать дальше...
by Jelmer Willems, Arthur P. H. de Jong, Nicky Scheefhals, Eline Mertens, Lisa A. E. Catsburg, Rogier B. Poorthuis, Fred de Winter, Joost Verhaagen, Frank J. Meye, Harold D. MacGillavry
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by Povilas Gibas, Milda Narmontė, Zdislav Staševskij, Juozas Gordevičius, Saulius Klimašauskas, Edita Kriukienė
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by Jian Heng, Peng Lv, Yifan Zhang, Xinjie Cheng, Lu Wang, Dongyuan Ma, Feng Liu
Читать дальше...A handful of well-known personalities have been out in front of the pandemic on social media.
Avengers: Endgame did a lot over the course of its bonkers, audacious runtime. For better or worse, it kind of had to. But trying to do so much, tying together 10 years of moviemaking into a single, only occasionally coherent narrative, inevitably meant that some plotlines just would not wrap up satisfyingly in the…
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| İnsan hücresine sadece virüs değil, radyasyon da giriyor! |
Men are more likely than women to die of the coronavirus,data from nearly 20 countries suggests. The pattern is particularly pronounced in Italy, where men represent nearly 70% of the country's deceased patients. More »
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