Common and rare SORLA single nucleotide polymorphisms have been associated with the development of Alzheimer's disease. So far, SORLA has been mainly studied in neurons, but the new study focused on SORLA's role in cancer cells. Led by Academy Professor Johanna Ivaska, researchers from the University of Turku in Finland observed that SORLA was highly expressed in HER2 positive cancers. Removing SORLA from cancer cells severely impaired the oncogenic fitness of HER2 positive cancers.
