Novak Djokovic, the second seed, crashed out of the US Open in the third round, losing to Alexei Popyrin, the 28th seed from Australia. Popyrin won 6-4, 6-4, 2-6, 6-4, advancing to the round of 16, marking his first time reaching this stage at a Grand Slam. Djokovic's loss is a significant upset.
